Effectiveness of Switching From Intravenous to Subcutaneous Infliximab in Patients With Inflammatory Bowel Diseases: the REMSWITCH Study.

Background And Aims: We assessed the effectiveness of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel diseases (IBDs) treated with or without intensified intravenous regimen.

Methods: In this multicenter observational study, IBD patients in clinical remission (partial Mayo score ≤2 or Harvey-Bradshaw index ≤4) were switched to a unique dose of subcutaneous infliximab (120 mg every other week). Pharmacological and biological data were collected at baseline, visit 1 (4-8 weeks postswitch), visit 2 (8-16 weeks postswitch), and visit 3 (16-24 weeks postswitch).

Global distribution of modern shallow-water marine carbonate factories: a spatial model based on environmental parameters.

Prediction of carbonate distributions at a global scale through geological time represents a challenging scientific issue, which is critical for carbonate reservoir studies and the understanding of past and future climate changes. Such prediction is even more challenging because no numerical spatial model allows for the prediction of shallow-water marine carbonates in the Modern. This study proposes to fill this gap by providing for the first time a global quantitative model based on the identification of carbonate factories and associated environmental affinities.