Human Genetic Susceptibility to Native Valve Endocarditis in Patients With Bacteremia: Genome-Wide Association Study.

infective endocarditis (SaIE) is a severe complication of bacteremia (SAB) occurring in up to 22% of patients. Bacterial genetic factors and host conditions for SaIE have been intensely studied before; however, to date no study has focused on predisposing host genetic factors to SaIE. The present study aimed to identify genetic polymorphisms associated with SaIE by a Genome-Wide Association Study (GWAS) of 67 patients with definite native valve SaIE (cases) and 72 matched native valve patients with SAB but without IE (controls).