Facial representations of complex affective states combining pain and a negative emotion.

Pain is rarely communicated alone, as it is often accompanied by emotions such as anger or sadness. Communicating these affective states involves shared representations. However, how an individual conceptually represents these combined states must first be tested.

"Plasma cell gingivitis" encompasses multiple entities: a retrospective series of 37 cases.

Background: Plasma cell gingivitis is defined as gingival inflammation comprised of plasma cell infiltrates. This diagnostic criterion is non-specific and underlying mechanisms remain unknown.

Objectives: We performed a multidisciplinary clinico-pathological review of cases previously identified as "gingivitis with plasma cell infiltrates", with assessment of putative contributing factors and critical appraisal of the final diagnosis.

[Basic, Clinical and Social Perspectives on the Use of Virtual Characters in Mental Health].

Along other breakthroughs in computer sciences, such as artificial intelligence, virtual characters (i.e. digitally represented characters featuring a human appearance or not) are foreseen as potential providers of mental healthcare services.

Pain evaluation and prosocial behaviour are affected by age and sex.

Background: Pain assessment and pain care are influenced by the characteristics of both the patient and the caregiver. Some studies suggest that the pain of older persons and of females may be underestimated to a greater extent than the pain of younger and male individuals.

Aims: This study investigated the effect of age and sex on prosocial behavior and pain evaluation.

Emotion regulation of others' positive and negative emotions is related to distinct patterns of heart rate variability and situational empathy.

Although emotion regulation has been proposed to be crucial for empathy, investigations on emotion regulation have been primarily limited to intrapersonal processes, leaving the interpersonal processes of self-regulation rather unexplored. Moreover, studies showed that emotion regulation and empathy are related with increased autonomic activation. How emotion regulation and empathy are related at the autonomic level, and more specifically during differently valenced social situations remains an open question.

Aging of speech production, from articulatory accuracy to motor timing.

Despite the huge importance of spoken language production in everyday life, little is known about the manner and extent to which the motor aspects of speech production evolve with advancing age, as well as the nature of the underlying senescence mechanisms. In this cross-sectional group study, we examined the relationship between age and speech production performance using a nonlexical speech production task in which spoken syllable frequency and phonological complexity were systematically varied to test hypotheses about underlying mechanisms. A nonprobabilistic sample of 60 cognitively healthy adults (18-83 years) produced meaningless nonwords aloud as quickly and accurately as possible.

Randomized trial of adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma.

The aim of this study was to demonstrate the interest of using tumor-infiltrating lymphocytes (TIL) as adjuvant therapy for stage III (regional lymph nodes) melanoma. After lymph node excision, patients without any detectable metastases were randomly assigned to receive either TIL plus interleukin-2 (IL-2) for 2 months, or IL-2 only. The primary endpoint was determination of the duration of the relapse-free interval.

Therapeutic efficacy of melanoma-reactive TIL injected in stage III melanoma patients.

Adoptive therapy for cancer using tumor-infiltrating lymphocytes (TIL) has mainly been investigated in cancer patients with advanced stage disease. The limited clinical success has not been encouraging, although this might be explained by poor TIL specificity and/or high tumor burden. To re-evaluate the effectiveness of adoptive therapy, we analyzed the capacity of tumor-reactive TIL injection in preventing the further development of disease in stage III melanoma patients after complete tumor resection.