Design, development and in-vitro evaluation of diclofenac taste-masked orodispersible tablet formulations.

Context: Fast onset of action is prerequisite for acute pain medication. A palatable orodispersible medicine of diclofenac providing rapid analgesic effect should improve patient compliance and treatment.

Objective: In the present study, diclofenac taste-masked orodispersible tablets (ODTs) with fast release characteristics were developed.

Design of biorelevant test setups for the prediction of diclofenac in vivo features after oral administration.

Purpose: Design of biorelevant test setups mimicking the physiological conditions experienced by drugs after oral administration along the passage through the mouth and the GI tract for the in vitro evaluation of diclofenac exhibiting multiple-peak phenomenon during absorption.

Methods: The biorelevant models simulated successively saliva (SSF, pH 6.2-6.

Development of oral taste masked diclofenac formulations using a taste sensing system.

To achieve patient compliance, organoleptic aspects of drug substances play a key role in the development of oral pharmaceutical preparations. In this study, the ability of an electronic tongue to help in selecting a drug candidate and rationalize the development of oral taste masked formulations was evaluated. As drug, diclofenac, in the form of acid, sodium salt and potassium salt, was used.