Publications by authors named "Marie Desaulniers"
Article Synopsis
- - The study investigates the issue of lymph node metastases in colorectal cancer, focusing on how misclassification in node negativity can lead to relapses in patients initially diagnosed as node-negative (pN0).
- - Researchers compared traditional histopathological analysis with a molecular method detecting guanylyl cyclase C (GCC) mRNA in lymph nodes from CRC patients, discovering that molecular methods significantly improve detection rates of cancer cells.
- - Findings suggest that detecting GCC in pN0 patients correlates with a greater likelihood of recurrence, indicating that this molecular approach may enhance prognostic assessments for earlier interventions following surgery.
Up to 30% of patients with stage II (pN0) colon cancer develop recurrences, suggesting that the presence of lymph node (LN) metastases escaped detection at histopathologic staging. A simple way to overcome this limitation and to improve staging accuracy is to use reverse transcription-polymerase chain reaction (RT-PCR) to examine a larger fraction or an entire specimen. The Guanylyl cyclase C (GCC) gene is uniquely expressed in apical cells of the gastrointestinal tract.
View Article and Find Full Text PDFObjectives: Men with elevated serum prostate-specific antigen (PSA) levels and negative prostate biopsy findings present a dilemma because of the lack of an accurate diagnostic test. We evaluated the potential utility of the investigational prostate cancer gene 3 (PCA3) urine assay to predict the repeat biopsy outcome.
Methods: Urine was collected after digital rectal examination (three strokes per lobe) from 233 men with serum PSA levels persistently 2.