Publications by authors named "Marie D Anderson"
Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal adhesions is under tension, which is higher in peripheral than central adhesions.
View Article and Find Full Text PDFInhibition of acetyl-CoA carboxylases (ACCs), a crucial enzyme for fatty acid metabolism, has been shown to promote fatty acid oxidation and reduce body fat in animal models. Therefore, ACCs are attractive targets for structure-based inhibitor design, particularly the carboxyltransferase (CT) domain, which is the primary site for inhibitor interaction. We have cloned, expressed, and purified the CT domain of human ACC2 using baculovirus-mediated insect cell expression system.
View Article and Find Full Text PDFArticle Synopsis
- Mycobacteriophages are a type of virus that specifically infect mycobacterial hosts, such as Mycobacterium smegmatis and Mycobacterium tuberculosis, and are characterized by their diverse genetic makeup.
- Recent research isolated and sequenced 18 new mycobacteriophages from different locations in the U.S., adding to the understanding of phage diversity and mobile elements in viral evolution.
- The study also emphasizes the educational aspect, showing how freshman college students can engage in real research by isolating and analyzing these bacteriophages.