Publications by authors named "Marie Christine Jaffar-Bandjee"
Aim: 2019-Coronavirus reached the French island of Reunion, which is marked by a very high prevalence of metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM), in March 2020. The objective was to determine the metabolic factors associated with the severity of SARS-CoV-2 infection in Reunion Island.
Methods: This retrospective observational cohort study enrolled patients who were hospitalized on the island from March 11th, 2020 to August 4th, 2021.
Genotypic and phenotypic characterisation of respiratory syncytial virus after nirsevimab breakthrough infections: a large, multicentre, observational, real-world study.
Lancet Infect Dis
October 2024
Article Synopsis
- A study conducted in France during the 2023-24 RSV season analyzed the effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV infections in infants, focusing on breakthrough cases.
- Out of 695 RSV-infected infants, researchers sequenced the full-length RSV genome of 545 infants, identifying that 48% had breakthrough infections despite receiving nirsevimab.
- While no resistance was found in RSV-A infections from nirsevimab-treated infants, two cases of RSV-B showed substitutions linked to resistance, indicating a potential concern for the antibody's effectiveness against this variant.
High risk human papillomavirus prevalence and genotype distribution in Reunion Island.
Eur J Obstet Gynecol Reprod Biol
October 2024
Article Synopsis
- The study aimed to evaluate the prevalence and types of human papillomavirus (HPV) in Reunion Island over a one-year period from 2020 to 2021.
- The overall HPV prevalence was found to be 14.5%, with the most common HPV types being clusters 56, 59, and 66, along with types 16 and 52; notably, vaccine-covered HPV types were present in over half of the HPV-positive cases.
- The research concluded that HPV types in the vaccine are most prevalent and linked to severe cervical issues, emphasizing the need to improve vaccination rates on the island to combat cervical cancer effectively.
Leptospirosis is a neglected zoonosis for which investigations assessing host-pathogen interaction are scarce. The aim of this study was to compare the severity and bacterial species involved in human cases of leptospirosis on Reunion and Mayotte islands, territories located in the southwest Indian Ocean that have recorded high human leptospirosis incidence but display fairly distinct epidemiological situations. A retrospective multicentric study including all patients over 18 years of age from Mayotte or Reunion with proven leptospirosis was conducted from January 2018 to April 2020.
View Article and Find Full Text PDFBackground: Dengue is a major public health concern in Reunion Island, marked by recurrent epidemics, including successive outbreaks of dengue virus serotypes 1 and 2 (DENV1 and DENV2) with over 70,000 cases confirmed since 2017.
Methodology/principal Findings: In this study, we used Oxford Nanopore NGS technology for sequencing virologically-confirmed samples and clinical isolates collected between 2012 and 2022 to investigate the molecular epidemiology and evolution of DENV in Reunion Island. Here, we generated and analyzed a total of 499 DENV1, 360 DENV2, and 18 DENV3 sequences.
Article Synopsis
- The study investigates the effectiveness of cefiderocol, an alternative drug for treating carbapenem-resistant Acinetobacter baumannii (CRAB) infections, particularly in a critically ill patient.
- The case presented shows initial treatment failure with colistin and tigecycline, but subsequent treatment with colistin and cefiderocol resulted in significant clinical improvement.
- The research highlights that adaptive resistance to cefiderocol (ARC) was noted in certain CRAB isolates, suggesting that cefiderocol may not be effective as a monotherapy for specific types of CRAB infections, warranting careful consideration of treatment options based on the strains present.
Molecular epidemiology identifies the expansion of the DENV2 epidemic lineage from the French Caribbean Islands to French Guiana and mainland France, 2023 to 2024.
Euro Surveill
March 2024
Article Synopsis
- - In 2023, dengue virus serotype 2 (DENV2) spread widely across French overseas territories, with over 30,000 suspected cases in the French Caribbean by March 2024.
- - Genome analysis shows that the DENV2 lineage in the Caribbean is now also found in French Guiana and has led to local cases in mainland France, but not in Réunion.
- - To prevent the further spread of the virus and its introduction in new areas, ongoing molecular monitoring and mosquito control efforts are crucial.
Background: Identifying predictors of severe dengue (SD) is key for triage and management of patients as well as for advising travellers to countries where dengue is endemic. In this, meta-analyses have raised diabetes mellitus as a risk factor for SD and a prognostic factor for dengue-related mortality. The purpose of this study was to assess whether diabetic patients (DPs) are at increased risk for SD in comparison to non-diabetic patients (NDPs) in a setting of high prevalence of type 2 diabetes mellitus and increasing endemicity for dengue.
View Article and Find Full Text PDFClinical manifestations of human leptospirosis: bacteria matter.
Front Cell Infect Microbiol
November 2023
Introduction: A high incidence of human leptospirosis is recorded on Mayotte, an oceanic island located in southwestern Indian Ocean, but the severity of the disease appears relatively mild in terms of mortality rate and admission to the intensive care unit. It has been proposed that mild leptospirosis may result from a limited virulence of some of the occurring species to which the population is exposed.
Methods: Clinical and biological data of patients admitted to the Centre Hospitalier de Mayotte were collected and the infecting species were determined through molecular typing.
Article Synopsis
- HPV is linked to various cancers, particularly cervical cancer, which has a higher incidence on Reunion Island compared to mainland France, highlighting the need for improved vaccination and screening efforts.
- The RUN-SurV-HPV study aims to explore the prevalence of different HPV genotypes among the young population at risk, examining factors like gender and anatomical sites.
- The research will analyze samples from 1200 patients aged 16 to 30, collected during routine STI testing from 2020 to 2022, to better understand HPV risks and support vaccination initiatives.
Clinical, epidemiologic, and microbiologic analyses revealed emergence of 26 cases of Corynebacterium diphtheriae species complex infections on Réunion Island, France, during 2015-2020. Isolates were genetically diverse, indicating circulation and local transmission of several diphtheria sublineages. Clinicians should remain aware of the risk for diphtheria and improve diagnostic methods and patient management.
View Article and Find Full Text PDFArticle Synopsis
- - Reunion Island has seen a resurgence of dengue outbreaks since 2018, with increasing severity and intensity, despite decades of low viral circulation.
- - A study conducted from 2018 to 2021 showed a rise in severe dengue cases and pediatric infections, with a notable shift in the dominant serotype from DENV2 to DENV1.
- - The findings suggest dengue is becoming endemic in the region, highlighting the need for health authorities to address the evolving public health implications associated with the disease.
Article Synopsis
- The incidence of dengue cases has surged in the past two decades, particularly influenced by urbanization, with many cases going unnoticed due to asymptomatic infections.
- A 2019 dengue outbreak in La Reunion led to over 18,000 confirmed cases, and a study involving 605 participants found low rates of active infections, but a significant number showed evidence of past infections.
- Research indicated that dengue transmission was localized, with most cases occurring within 100 meters and under a week apart, and environmental factors like housing type and street cleanliness were linked to infection rates, rather than demographic characteristics.
Article Synopsis
- Certain extensively drug-resistant Enterococcus faecium (E. faecium) strains are exhibiting dual resistance to linezolid and glycopeptides, highlighting a significant health challenge on Reunion Island, where a recent outbreak of linezolid- and vancomycin-resistant E. faecium (LVREf) occurred.
- A study analyzed vancomycin-resistant E. faecium isolates from 2015 to 2019, identifying a cluster of seven outbreak isolates in 2019 linked to an imported strain from India, along with a notable genetic profile that included resistance genes.
- The findings emphasize the urgent need for stringent infection control measures to prevent the spread of these resistant strains and address the public health risks associated
Article Synopsis
- Cervical cancer (CC) is a leading cause of death that predominantly arises from HPV infections, and underserved women face higher risks due to lower screening rates.
- A cluster randomized trial will assess the impact of financial incentives and different self-sampling return methods on increasing HPV screening rates among 10,000 women aged 30-65 in deprived areas of France.
- The study has received ethical approval, requires no formal consent, and will collect follow-up data through the National Health Insurance to evaluate if incentives can raise HPV self-sampling return rates by at least 10%.
Article Synopsis
- Island communities provide a unique setting for studying microbial evolution during epidemics due to their limited population connectivity, as seen on Reunion Island during the early COVID-19 pandemic.
- In 2021, the SARS-CoV-2 Beta variant surged in Reunion Island before being replaced by the Delta variant, highlighting the island's role in genomic evolution.
- The isolation of islands can lead to the emergence of distinct genetic lineages, making them important areas for understanding the ongoing evolution and spread of COVID-19 variants.
The aim of this study was to compare the prognosis of patients with acute respiratory failure (ARF) due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant 501Y.V2 to that of patients with ARF due to the original strain. This retrospective matched cohort study included all consecutive patients who were hospitalized for ARF due to SARS-CoV-2 in Reunion Island University Hospital between March 2020 and March 2021.
View Article and Find Full Text PDFBackground: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a major cause of infections worldwide. An understanding of the reservoirs and modes of transmission of these pathogens is essential, to tackle their increasing frequency.
Objectives: We investigated the contributions of various compartments (humans, animals, environment), to human colonization or infection with ESBL-Ec over a 3 year period, on an island.
In February 2021, an explosion of cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia overwhelmed the only hospital in Mayotte. To report a case series of patients with acute respiratory failure (ARF) due to SARS-CoV-2 who were evacuated by air from Mayotte to Reunion Island.This retrospective observational study evaluated all consecutive patients with ARF due to SARS-CoV-2 who were evacuated by air from Mayotte Hospital to the intensive care unit (ICU) of Félix Guyon University Hospital in Reunion Island between February 2, and March 5, 2021.
View Article and Find Full Text PDFArticle Synopsis
- Legionella sainthelensi is a rare bacterium linked to severe cases of Legionnaires' disease, first isolated in 1980 from water near Mt. St-Helens, but there is limited data on it.
- A documented case involved a 35-year-old woman with Sharp's syndrome, who developed severe pneumonia caused by L. sainthelensi after being treated with hydroxychloroquine and corticosteroids; she eventually improved with macrolide treatment in the ICU.
- Currently, only 14 cases of L. sainthelensi infections have been reported globally, highlighting the challenge of diagnosing this pathogen, as common tests often miss it, leading to underdiagnosis in patients presenting with pneumonia symptoms.
Dual resistance to colistin and carbapenems is a milestone reached by certain extensively-drug resistant (XDR) Gram-negative bacteria. This study describes the first outbreak of XDR colistin- and carbapenem-resistant OXA-23-/NDM-1-producing Acinetobacter baumannii (CCRAB) in the European overseas territory of Reunion Island (France, Indian Ocean). Between April 2019 and June 2020, 13 patients admitted to the University Hospital of Reunion Island were involved in the outbreak, of whom eight were infected and six died.
View Article and Find Full Text PDFOBJECTIVES Congenital cytomegalovirus infection (cCMV) affects around 3400 newborns each year in France, of whom 700 will develop sequelae, primarily sensorineural hearing loss. Our objectives were (1) to evaluate incidence of cCMV in two French departments located in the Indian Ocean: Mayotte and La Reunion, and (2) evaluate interest and feasibility/acceptability of universal screening of cCMV at birth. MATERIAL AND METHODS We implemented a universal neonatal CMV screening in Mayotte during 7 months in 2019 and in La Reunion during one month in March 2020.
View Article and Find Full Text PDFPatients following infection by chikungunya virus (CHIKV) can suffer for months to years from arthralgia and arthritis. Interestingly, methotrexate (MTX) a major immune-regulatory drug has proved to be of clinical benefit. We have previously shown that CHIKV can persist in the joint of one patient 18 months post-infection and plausibly driving chronic joint inflammation but through ill-characterized mechanisms.
View Article and Find Full Text PDFBackground: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia.
Methods: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island.
Results: Over the study period, 164 out of 398 patients (41.