Publications by authors named "Marie C Remolano"
Article Synopsis
- Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, with limited understanding of its biological mechanisms due to insufficient genomic studies.
- A study analyzing data from 2457 patients found that IBC cases were generally diagnosed at a younger age and had higher grades, with significant associations to hormone receptor-negative and HER2-positive tumors.
- The research revealed frequent somatic alterations in IBC, particularly in HER2-positive cases, and highlighted the NOTCH pathway's potential involvement, while overall genomic differences between IBC and non-IBC were minimal, suggesting the complexity of IBC pathology.
Background: Patients with inflammatory breast cancer (IBC) have a high risk of central nervous system metastasis (mCNS). The purpose of this study was to quantify the incidence of and identify risk factors for mCNS in patients with IBC.
Methods: The authors retrospectively reviewed patients diagnosed with IBC between 1997 and 2019.
Rationale And Objectives: Preoperative systemic therapy (PST) followed by mastectomy and radiation improves survival for patients with inflammatory breast cancer (IBC). Residual disease within the skin post-PST adversely impacts surgical outcome and risk of local-regional recurrence (LRR). We aimed to assess magnetic resonance imaging (MRI) breast skin changes post-PST with pathologic response and its impact on surgical resectability.
View Article and Find Full Text PDFObjectives: Dermal lymphatic invasion (DLI) with tumor emboli is a common pathologic characteristic of inflammatory breast cancer (IBC), although its presence is not required for diagnosis. We examined whether documented DLI on skin biopsy was associated with survival and time to recurrence or progression in IBC.
Materials And Methods: A total of 340 women enrolled in the IBC Registry at Dana-Farber Cancer Institute between 1997 and 2019 were included in this study.