Mesoporous Biodegradable Magnesium Phosphate-Citrate Nanocarriers Amplify Methotrexate Anticancer Activity in HeLa Cells.

We present the synthesis of amorphous, mesoporous, colloidal magnesium phosphate-citrate nanoparticles (MPCs) from biogenic precursors, resulting in a biocompatible and biodegradable nanocarrier that amplifies the action of the anticancer drug methotrexate (MTX). Synthesis conditions were gradually tuned to investigate the influence of the chelating agent citric acid on the colloidal stability and the mesoporosity of the obtained nanoparticles. With optimized synthesis conditions, a large BET surface area of 560 m/g was achieved.

Strengthening of the C-F Bond in Fumaryl Fluoride with Superacids.

The reaction of fumaryl fluoride with the superacidic solutions XF/MF (X=H, D; M=As, Sb) results in the formation of the monoprotonated and diprotonated species, dependent on the stoichiometric ratio of the Lewis acid to fumaryl fluoride. The salts [C H F O ] [MF ] (M=As, Sb) and [C H X F O ] ([MF ] ) (X=H, D; M=As, Sb) are the first examples with a protonated acyl fluoride moiety. They were characterized by low-temperature vibrational spectroscopy.

Tuning the Anomeric Effect in Sulfamide with Superacids.

This study shows that the anomeric effect (negative hyperconjugation) that arises in sulfamide, as a result of the relatively short S-N bonds, can be tuned by the utilization of superacidic media. Sulfamide was reacted in binary superacidic systems XF/MF (M=As, Sb; X=H, D) and HF/BF . The colorless salts formed, [X NSO NX ] [MF ] and [H NSO NH ] [BF ] were characterized by low-temperature vibrational spectroscopy.