Routine Supercritical Fluid Chromatography Tandem Mass Spectrometry Method for Determination of Vitamin K1 Extracted from Serum with a 96-Well Solid-Phase Extraction Method.

Background: The concentration of vitamin K1 in serum or plasma is the most common index for assessing vitamin K status. The aim of this study was to develop and validate a rapid and reliable routine method for quantifying vitamin K1 above 0.1 ng/mL.

Interference of common haemoglobin variants with the Tosoh G7 standard mode HbA1c method.

Background: HbA1c methods may be prone to interference by the presence of haemoglobin variants. In contrast to the variant mode of the HbA1c method on the Tosoh G7 instrument, the literature lacks investigations of haemoglobin variant interference with the standard mode. The current study sought to investigate whether different haemoglobin variants interfere with the Tosoh G7 standard mode HbA1c method, and whether present haemoglobin variants are identifiable on respective chromatograms.

[Evaluation of the genetic lactose intolerance test].

Background: Lactose intolerance afflicts 5-10% of the population in western Europe, but is very common (up to 90%) in the southern hemisphere. Traditional analysis methods are based on lactose intake followed by determination of blood glucose concentration or exhaled H 2 and CH 4 . In many diagnostic laboratories, single nucleotide polymorphism (SNP) analysis on C/T-13910 has been introduced as a replacement for the traditional lactose intolerance testing.