Publications by authors named "Marie Aurel"
Article Synopsis
- Blood cultures in children with community-acquired pneumonia (CAP) often yield negative results, prompting the study of various biomarkers to predict the presence of bacteremia.
- A study of 13,752 children found that while blood culture was positive in only 3.6% of cases, levels of absolute neutrophils count (ANC), C-reactive protein (CRP), and procalcitonin (PCT) were significantly higher in those with bacteremia.
- Of the biomarkers tested, PCT was the most reliable for predicting bacteremia, outperforming white blood cell counts, and CRP stood out as the best routinely available biomarker for this condition.
Importance: In several countries, 5 years after 13-valent pneumococcal conjugate vaccine (PCV13) implementation, serotype replacement has been reported for invasive pneumococcal disease, which raises concerns about the long-term outcome of PCV13 implementation. The long-term effect of vaccination on community-acquired pneumonia (CAP) remains unknown.
Objective: To assess the long-term outcome of PCV13 implementation on CAP in children.
Background: Many countries have observed an early and strong impact of implementation of the 13-valent pneumococcal conjugate vaccine (PCV13) on community-acquired pneumonia (CAP). High levels of C-reactive protein (CRP) and procalcitonin (PCT) are considered biomarkers of bacterial infection (particularly infection due to pneumococcus); therefore, PCV13 implementation should have different effectiveness on CAP depending on the levels of these two biomarkers. To demonstrate this assumption, we analyzed the evolution of number of CAP cases seen in pediatric emergency departments in France after PCV13 implementation (in 2010) by levels of these two biomarkers.
View Article and Find Full Text PDFImported malaria in children: incidence and risk factors for severity.
Diagn Microbiol Infect Dis
February 2010
To assess the incidence of imported malaria in children and to determine the frequency of delayed diagnosis and risk factors for severe malaria, we performed a retrospective multicenter cohort study in the northern region of France and included all children with a positive test for malaria from 2000 to 2006. The incidence of imported malaria in children <18 years, the frequency of a delayed diagnosis, and the risk factors for severe malaria were determined. The study identified 133 children with imported malaria.
View Article and Find Full Text PDFArticle Synopsis
- Acute diarrhea in children in France is common and can lead to serious health issues, making the accurate diagnosis of dehydration important for treatment.
- A review of studies found no single clinical sign or lab result could reliably identify dehydration; instead, a combination of at least three clinical signs is more effective.
- Current research lacks strong validation for diagnosing dehydration in children, indicating a need for further studies to improve diagnostic accuracy.