Publications by authors named "Marichen Van der Merwe"
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Synopsis of recent research by authors named "Marichen Van der Merwe"
- Marichen Van der Merwe's research primarily focuses on the biochemical interactions and inhibitors related to reverse transcriptase enzymes, specifically in the context of retroviruses like the Moloney murine leukemia virus.
- One of her significant studies involves the synthesis and analysis of N-acylated derivatives of amino-adenosine compounds, demonstrating their inhibitory effects on DNA synthesis catalyzed by the Moloney leukemia virus reverse transcriptase.
- The findings reveal that certain derivatives, such as N-palmitoyl and N-nicotinyl compounds, exhibit partial inhibition of this enzyme, indicating potential pathways for developing antiviral strategies.
