Publications by authors named "Marichen Van der Merwe"

N-Acylated derivatives of 8-(6-aminohexyl) amino-adenosine-5 '-phosphate were prepared and studied with regard to their effect on DNA synthesis by the Moloney leukemia virus reverse transcriptase. N-palmitoyl and N-nicotinyl derivatives and bis-8-(6-aminohexyl) amino-5'-AMP inhibited the enzyme partially using poly (rA).oligo d(pT)(16-18) as template-primer with [(3)H]dTTP.

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Synopsis of recent research by authors named "Marichen Van der Merwe"

  • - Marichen Van der Merwe's research primarily focuses on the biochemical interactions and inhibitors related to reverse transcriptase enzymes, specifically in the context of retroviruses like the Moloney murine leukemia virus.
  • - One of her significant studies involves the synthesis and analysis of N-acylated derivatives of amino-adenosine compounds, demonstrating their inhibitory effects on DNA synthesis catalyzed by the Moloney leukemia virus reverse transcriptase.
  • - The findings reveal that certain derivatives, such as N-palmitoyl and N-nicotinyl compounds, exhibit partial inhibition of this enzyme, indicating potential pathways for developing antiviral strategies.