Publications by Marichen Van der Merwe

Publications by authors named "Marichen Van der Merwe"

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Studies on the inhibition of Moloney murine leukemia virus reverse transcriptase by N-tritylamino acids and N-tritylamino acid-nucleotide compounds.

Arthur Hawtrey Anton Pieterse Johann van Zyl Pieter Van der Bijl Marichen Van der Merwe

Nucleosides Nucleotides Nucleic Acids

September 2008

N-Acylated derivatives of 8-(6-aminohexyl) amino-adenosine-5 '-phosphate were prepared and studied with regard to their effect on DNA synthesis by the Moloney leukemia virus reverse transcriptase. N-palmitoyl and N-nicotinyl derivatives and bis-8-(6-aminohexyl) amino-5'-AMP inhibited the enzyme partially using poly (rA).oligo d(pT)(16-18) as template-primer with [(3)H]dTTP.

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- Marichen Van der Merwe's research primarily focuses on the biochemical interactions and inhibitors related to reverse transcriptase enzymes, specifically in the context of retroviruses like the Moloney murine leukemia virus.
- One of her significant studies involves the synthesis and analysis of N-acylated derivatives of amino-adenosine compounds, demonstrating their inhibitory effects on DNA synthesis catalyzed by the Moloney leukemia virus reverse transcriptase.
- The findings reveal that certain derivatives, such as N-palmitoyl and N-nicotinyl compounds, exhibit partial inhibition of this enzyme, indicating potential pathways for developing antiviral strategies.

Publications by authors named "Marichen Van der Merwe"

Studies on the inhibition of Moloney murine leukemia virus reverse transcriptase by N-tritylamino acids and N-tritylamino acid-nucleotide compounds.

Synopsis of recent research by authors named "Marichen Van der Merwe"