Publications by authors named "Maribel Mosqueda"
Implementing evidence-based practice (EBP) in a safety net healthcare system is challenging. This study examined factors associated with feasibility and potential facilitators and barriers which might affect the implementation of a new evidence-based comprehensive primary care and community health-based program aiming to promote efficient and equitable delivery of Lung Cancer Screening and Tobacco Cessation (LCS-TC). Fifty-three key informants were interviewed.
View Article and Find Full Text PDFGenetic aberrations driving pro-oncogenic and pro-metastatic activity remain an elusive target in the quest of precision oncology. To identify such drivers, we use an animal model of KRAS-mutant lung adenocarcinoma to perform an in vivo functional screen of 217 genetic aberrations selected from lung cancer genomics datasets. We identify 28 genes whose expression promoted tumor metastasis to the lung in mice.
View Article and Find Full Text PDFBackground: Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and genomic factors compared to bladder cancer.
Objective: To characterize the genomic landscape of UTUC and provide insights into its biology using comprehensive integrated genomic analyses.
Design, Setting, And Participants: We collected 31 untreated snap-frozen UTUC samples from two institutions and carried out whole-exome sequencing (WES) of DNA, RNA sequencing (RNAseq), and protein analysis.
Article Synopsis
- Recent studies reveal that A-to-I RNA editing in microRNAs impacts tumor growth and metastasis, but its effects in melanoma are unclear.
- Evidence shows that low expression of ADAR1 in metastatic melanoma is linked to CREB, and re-introduction of ADAR1 suppresses tumor growth and metastasis.
- The miRNA miR-455-5p, which has A-to-I editing sites, functions differently when edited; the unedited form promotes melanoma metastasis, while the edited version inhibits it, highlighting the role of RNA editing in cancer progression.