Publications by authors named "Mariateresa Cocule"
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20% of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial role in various cellular processes, including growth, differentiation, apoptosis, epithelial-mesenchymal transition (EMT), regulation of the extracellular matrix, angiogenesis, and immune responses. TGF-β signals through SMAD proteins, which are intracellular molecules that transmit TGF-β signals from the cell membrane to the nucleus.
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- Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent pancreatic cancer type and is a major cause of cancer-related deaths, with poor prognosis even post-surgery.* -
- This study analyzed the expression of certain microRNAs in PDAC patients, finding that miR-1-3p, miR-31-5p, and miR-205-5p were significantly upregulated in higher-grade tumors and in patients with lymph node metastases.* -
- The findings suggest that these miRNAs could serve as potential biomarkers for early diagnosis and treatment strategies in PDAC, indicating a need for further research in this area.*