Publications by authors named "Mariassunta Tedesco"
Int J Mol Sci
September 2024
Article Synopsis
- PDIA3 is an important protein in the endoplasmic reticulum that plays a key role in protein folding and is linked to diseases like cancer and neurodegeneration.
- Punicalagin is a promising but non-selective PDIA3 inhibitor, prompting the exploration of its derivative, punicalin, which has a simpler structure and better selectivity towards PDIA3.
- Studies show that punicalin effectively binds and inhibits PDIA3, demonstrating higher selectivity compared to PDIA1, and causes significant changes in PDIA3's thermal stability, highlighting its potential for developing selective PDIA3 inhibitors.
