[The progesterone receptor gene polymorphism as factor of risk for the preterm delivery].

Purpose: to investigate the association between gene polymorphism of the progesterone receptor (PROGINS) and the risk of premature birth.

Methods: In this case-control study, 57 women with previous premature delivery (Case Group) and 57 patients with delivery at term in the current pregnancy and no history of preterm delivery (Control Group) were selected. A 10 mL amount of peripheral blood was collected by venipuncture and genomic DNA was extracted followed by the polymerase chain reaction (PCR) under specific conditions for this polymorphism and 2% agarose gel electrophoresis.

[Endometrial polyps: clinical and epidemiological aspects and analysis of polymorphisms].

Purpose: To evaluate the clinical and epidemiological risk factors for endometrial cancer in postmenopausal women with endometrial polyps, as well as the genetic polymorphism of the progesterone receptor (PROGINS).

Methods: A case-control study was designed with 160 postmenopausal women with endometrial polyps, compared to a normal Control Group of 400 postmenopausal women. The genotyping of PROGINS polymorphism was determined by the polymerase chain reaction.