Publications by authors named "Mariano Manzionna"

Background: represents an important issue in the medico-legal and social context. In the last few decades, various aspects and mechanisms have been identified in case studies; however, constant research is needed in the field. With this paper, the authors will present a case of a new entity of that has come to the attention of medico-legal experts.

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Recent literature suggests that lung ultrasound might have a role in the diagnosis and management of bronchiolitis. The aim of the study is to evaluate the relationship between an ultrasound score and the clinical progression of bronchiolitis: need for supplemental oxygen, duration of oxygen therapy and hospital stay. This was a prospective observational single-center study, conducted in a pediatric unit during the 2017-2018 epidemic periods.

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Introduction: Viral bronchiolitis is a common cause of lower respiratory tract infection in the first year of life, considered a health burden because of its morbidity and costs. Its diagnosis is based on history and physical examination and the role of radiographic examination is limited to atypical cases. Thus far, Lung Ultrasound (LUS) is not considered in the diagnostic algorithm for bronchiolitis.

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Macrolide-resistant Mycoplasma pneumoniae (MR-MP) is an increasing problem worldwide. This study describes the clonal spread of a unique strain of MR-MP within a single family. On January 23, 2015, nasopharyngeal swabs and sputum samples were collected from the index case (a 9-year-old girl) in southern Italy.

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Background: Clinical assessment is the gold standard for diagnosis of bronchiolitis. To date, only one study found LUS (Lung Ultrasound) to be a valuable tool in the diagnosis of bronchiolitis. Aim of this study is to evaluate the accuracy of lung ultrasonography in the diagnosis and management of bronchiolitis in infants.

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Here we describe a case of paediatric visceral leishmaniasis recorded in an infant initially suspected for acute lymphoblastic leukaemia due to the clinical and haematological presentation. Eventually the patient was found positive for Leishmania infantum infection and successfully treated. This case emphasises how pivotal a 'One Health' approach is for diagnosing this zoonotic disease; highlighting the importance of including Visceral Leishmaniasis in the differential diagnosis of leukaemia-like syndromes in infants travelling to, and living in, the Mediterranean region.

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Article Synopsis
  • * Out of 937 pregnant women with HIV-1, a small percentage interrupted ART, with a notable increase in mother-to-child transmission rates during these interruptions: 4.9% when interrupted in the first trimester and 18.2% in the third trimester.
  • * The findings indicate that discontinuing ART during pregnancy significantly raises the risk of transmission, emphasizing the need for consistent treatment throughout pregnancy to minimize this risk.
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Purpose: To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period.

Patients And Methods: An observational population study was conducted on 1,190 perinatally HIV-infected children enrolled onto the Italian Register for HIV Infection in Children from 1985 to 2004 and never lost to follow-up (total observation time, 10,037.66 years).

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