From ligand to complexes. Part 2. Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes.

Previously, we synthesized a series of beta-diketo acid metal complexes as novel HIV-1 integrase (IN) inhibitors (J. Med. Chem.

Unusual behavior of the aqueous solutions of gemini bispyridinium surfactants: apparent and partial molar enthalpies of the dimethanesulfonates.

Apparent and partial molar enthalpies at 298 K of the aqueous solutions of cationic gemini surfactants 1,1'-didodecyl-2,2'-dimethylenebispyridinium dimethanesulfonate (12-Py(2)-2-(2)Py-12 MS); 1,1'-didodecyl-2,2'-trimethylenebispyridinium dimethanesulfonate (12-Py(2)-3-(2)Py-12 MS); 1,1'-didodecyl-2,2'-tetramethylenebispyridinium dimethanesulfonate (12-Py(2)-4-(2)Py-12 MS); 1,1'-didodecyl-2,2'-octamethylenebispyridinium dimethanesulfonate (12-Py(2)-8-(2)Py-12 MS); 1,1'-didodecyl-2,2'-dodecamethylenebispyridinium dimethanesulfonate (12-Py(2)-12-(2)Py-12 MS) were measured as a function of concentration and are here reported for the first time. They show a very peculiar behavior as a function of the spacer length, not allowing for the determination of a -CH 2- group contribution when this group is added to the spacer. The curve of the compound with a four-carbon-atom-long spacer lies between those of the compound with a spacer of 2 and 3 carbon atoms, instead of that below the latter, as expected.

Thermodynamics and biological properties of the aqueous solutions of new glucocationic surfactants.

Thermodynamic properties of aqueous solutions of newly synthesized compounds, namely, N-[2-(beta-D-glucopyranosyl)ethyl]-N,N-dimethyl-N-alkylammonium bromides with hydrophobic tails of 12 (C12DGCB) and 16 (C16DGCB) carbon atoms, determined as a function of concentration by means of direct methods, are reported here. Dilution enthalpies, densities, and sound velocities were measured at 298 K, allowing for the determination of apparent and partial molar enthalpies, volumes, and compressibilities. Changes in thermodynamic quantities upon micellization were derived using a pseudophase-transition approach.

Thermodynamics of aqueous solutions of dodecyldimethylethylammonium bromide.

The thermodynamic properties of the aqueous solutions of dodecyldimethylethylammonium bromide (DEDAB) were determined as a function of concentration by means of direct methods. Dilution enthalpies at 298 and 313 K, densities and sound velocities at 298 K were measured, allowing the determination of apparent and partial molar enthalpies, volumes, heat capacities and compressibilities. Changes in thermodynamic quantities upon micellization were derived using a pseudo-phase transition approach.