Effects of autoimmune antibodies anti-lipoprotein lipase, anti-low density lipoprotein, and anti-oxidized low density lipoprotein on lipid metabolism and atherosclerosis in systemic lupus erythematosus.

Introduction: Premature development of atherosclerosis in systemic lupus erythematosus has been widely reported. Anti-lipoprotein lipase antibody may be one cause contributing to this disorder.

Objective: To assess the extent of coronary risk due to autoimmune antibodies in terms of carotid plaque in lupus patients.

Correlations of anti-dsDNA and anti-ribosomal P autoantibodies with lupus nephritis.

Patients with systemic lupus erythematosus, with and without nephritis, were studied for their serological profiles. Patients were stratified into two groups defined by the presence or the absence of precipitating antibodies to ribosomal P proteins. It was found that 27 patients were positive for anti-P precipitins and the remaining 34 patients were studied for the presence of lesser amounts of anti-P antibodies by Western blot and ELISA tests.

Autoantibodies to lipoprotein lipase and dyslipidemia in systemic lupus erythematosus.

Objective: To demonstrate the binding of bovine lipoprotein lipase (LPL) by IgG from sera obtained from patients with systemic lupus erythematosus (SLE) and other rheumatic diseases, and the relationship of anti-LPL to triglyceride levels in SLE.

Method: Binding of LPL by IgG from sera obtained from patients with SLE and other rheumatic diseases was measured by an enzyme-linked immunosorbent assay technique. Lipid profiles for fasting blood samples obtained from SLE patients and control subjects were determined.