Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity.

Background: Patients with inborn errors of immunity (IEI) are at increased risk of severe coronavirus disease-2019 (COVID-19). Effective vaccination against COVID-19 is therefore of great importance in this group, but little is known about the immunogenicity of COVID-19 vaccines in these patients.

Objectives: We sought to study humoral and cellular immune responses after mRNA-1273 COVID-19 vaccination in adult patients with IEI.

Endocrine Disorders Are Prominent Clinical Features in Patients With Primary Antibody Deficiencies.

Primary antibody deficiencies (PADs) and anterior pituitary dysfunction are both rare conditions. However, recent studies have remarkably reported the occurrence of anterior pituitary dysfunction in PAD patients. In this cross-sectional, single-center study we evaluated the prevalence of endocrine disorders in adult PAD patients.