Publications by authors named "Marianne Tokic"
Article Synopsis
- - Primary ciliary dyskinesia (PCD) is a rare genetic disorder affecting cilia function, impacting respiratory health, with no cure available; supportive therapies like physical activity are recommended despite a lack of scientific backing.
- - A multi-center randomized controlled trial will involve 158 participants to test whether a personalized physical activity program improves quality of life (QoL) compared to standard recommendations over six months, utilizing activity trackers and regular assessments.
- - The trial aims to address challenges posed by the diversity of PCD cases and age variation through stratified randomization, emphasizing individualized approaches and maintaining close contact with trainers to enhance outcomes.
Article Synopsis
- Multiple sclerosis is a disease where the immune system attacks the nervous system, making it hard to find effective treatments to fully fix it.
- Scientists are studying how diet, especially high-fiber foods, can help by producing beneficial substances like propionic acid, which might help protect nerve cells.
- In experiments, they found that propionic and butyric acid helped damaged nerve cells recover better, which could lead to new ways to help people with multiple sclerosis.
Early postpartum treatment strategies and early postpartum relapses in women with active multiple sclerosis.
J Neurol Neurosurg Psychiatry
January 2024
Background: Relapse risk after delivery is increased in women with active multiple sclerosis (MS), the best strategy to reduce it is unknown. We aimed to assess the association of four different postpartum strategies with relapses during the first 6 months post partum.
Methods: This cohort study includes data prospectively collected through structured telephone interviews from the German Multiple Sclerosis and Pregnancy Registry.
Multiple Sclerosis Disease Activity and Disability Following Cessation of Fingolimod for Pregnancy.
Neurol Neuroimmunol Neuroinflamm
July 2023
Article Synopsis
- Discontinuing fingolimod two months before pregnancy is advised to reduce risks for fetal harm, but the impact on pregnancy-related MS relapses is still unclear.
- A study involving 213 pregnancies tracked relapse rates in women who stopped fingolimod before or during pregnancy, revealing high incidence rates of relapses both during pregnancy and postpartum.
- Approximately 6% of women experienced significant disability due to severe relapses after stopping fingolimod, with most relapses occurring within the first three months after giving birth.
Background: Since hearing loss and cognitive decline often co-occur among older adults, a cognitive screening test suitable for hearing-impaired people is of high clinical relevance. We report the first evaluation of a German language version of the Montreal Cognitive Assessment-Hearing Impaired version (MoCA-HI).
Objective: The aim of the present study was to compare cognitively healthy participants with and without hearing loss, to examine the impact of age, sex, educational level and degree of hearing impairment on the German MoCA-HI performance, and to develop normative data.
Importance: The magnitude of risk of pregnancy-related multiple sclerosis relapses, particularly severe relapses, following natalizumab cessation is unclear, as is whether this risk is reduced by pregnancy or other modifiable factors.
Objective: To determine the association of early natalizumab withdrawal before or during pregnancy with risk of severe relapses and relapse-related disability.
Design, Setting, And Participants: This prospective cohort study used data from the German Multiple Sclerosis and Pregnancy Registry, which enrolled participants between November 2006 and February 2018.