Risk factors for tooth loss and progression of periodontitis in patients undergoing periodontal maintenance therapy.

Aim: The aim of this study was to investigate patient- and tooth-level factors that may predict tooth loss and periodontitis progression in patients who have undergone at least 5 years of periodontal maintenance.

Materials And Methods: In this retrospective cohort study, 135 patients were examined after active periodontal therapy (APT) and periodontal maintenance for 5.09-8.

The efficacy of probiotics in the management of intra-oral halitosis: a systematic review.

Objectives: To evaluate the efficacy of probiotics in reducing halitosis of dental origin.

Methods: MEDLINE, EMBASE, and CENTRAL were searched up to and including June 2020. Randomised placebo-controlled, double-blinded clinical trials in systemically healthy adult patients who were given any form of probiotics to manage halitosis of dental origin were included.

Comparative Efficacy of Different Flapless Ridge Preservation Techniques: A Systematic Review and Meta-Analysis.

Although the efficacy of ridge preservation is well documented, there is a lack of robust evidence regarding the influence of different surgical techniques. Flapless approaches are thought to be better at preserving soft tissue architecture and have been suggested for mild to moderate defects. This review investigates the efficacy of different flapless techniques for ridge preservation in mild to moderate defects with <50% buccal bone loss.

Minimally Invasive Periodontology: A Treatment Philosophy and Suggested Approach.

Severe periodontitis is a highly prevalent dental disease. With the advent of implant dentistry, teeth are often extracted and replaced. Periodontal surgery, where indicated, could also result in increased trauma to the patient.

Adjunctive probiotics after periodontal debridement versus placebo: a systematic review and meta-analysis.

Objective: To comprehensively investigate the efficacy of adjunctive probiotics compared to placebo, using conventional and novel treatment outcomes.

Materials And Methods: Three databases (MEDLINE, EMBASE, and CENTRAL) were searched. Outcomes included percent change in the total number of deep sites before and after therapy, change in mean probing pocket depth (mm), percentage patients requiring additional therapy, risk for disease progression, and microbiological and immunological results.

Metagenomic sequencing provides new insights into the subgingival bacteriome and aetiopathology of periodontitis.

"Open-ended" molecular techniques such as 16S rRNA sequencing have revealed that the oral bacteriome of subgingival plaque is more diverse than originally thought. 16S rRNA analysis has demonstrated that constituents of the overall bacterial community are qualitatively similar in health and disease, differing mainly in their relative proportions with respect to each other. Species in low abundance can also act as critical species, leading to the concept of global community dysbiosis which relates to shifts in community structure, rather than shifts in membership.

A Risk-Based Approach to the COVID-19 Pandemic: The Experience in National Dental Centre Singapore.

The emergence of a highly infectious coronavirus strain, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a major global public health emergency. The increasing number of infected cases and fatalities worldwide forced several countries into lockdown in a bid to control virus transmission. The practice of dentistry is considered high-risk due to the generation of aerosols associated with most dental procedures, and healthcare professionals must take appropriate precautions whilst working in this challenging environment.

Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects.

Resveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent dimethyl sulfoxide (DMSO) hinder translation to clinical applicability. Our study aimed to investigate the comparative antimicrobial properties of RES and its analogues (pterostilbene [PTS], oxyresveratrol [OXY] and piceatannol [PIC]), utilizing 2-hydroxypropyl-β-cyclodextrin (HPβCD) as a solubiliser, which has a well-documented safety profile and FDA approval.

Application of BMP-Bone Cement and FGF-Gel on Periodontal Tissue Regeneration in Nonhuman Primates.

The ultimate challenge of tissue engineering research is the translation of experimental knowledge into clinical application. In the preclinical testing phase of any new therapy, animal models remain the gold standard. Therefore, the methodological choice of a suitable model is critical to meet the requirements for a safe clinical application of the developed treatment.

Anatomical, microbiological, and genetic considerations in treatment of Chinese periodontal patients.

The aim of the present narrative review was to highlight considerations when treating Chinese patients with periodontal diseases. These considerations can be broadly categorized into anatomical, microbiological, and genetic considerations. Anatomical considerations are tooth-related factors causing site-specific issues, and these include incisal palatal groove, root concavities, three-rooted permanent mandibular first molar, furcation entrance dimensions, cervical enamel projections, root trunk length, and molar root fusion.

Gingival profiles in a select Asian cohort: A pilot study.

Aim: The aim of the present study was to determine the facial gingival profiles of teeth with a healthy periodontium in an Asian population.

Methods: A total of 51 patients with a healthy periodontium were examined. Gingival thickness (GT) and gingival width (GW) were assessed at the maxillary and mandibular incisors to the first molars.

Influence of maintenance care in periodontally susceptible and non-susceptible subjects following implant therapy.

Objectives: To compare the periodontal and peri-implant conditions of periodontally susceptible and periodontally healthy subjects under maintenance care for a period of at least 3 years.

Material And Methods: Sixty periodontally susceptible patients (PSP) and 56 periodontally non-susceptible subjects (PHS) were treated with dental implants in the National Dental Centre Singapore (NDCS) and were maintained in a regular supportive periodontal care program for a mean of 6 years. Full mouth bleeding on probing (BoP), full mouth probing pocket depths (PPD), implant loss, and absence of crestal bone loss were recorded at the time of prosthesis delivery and following a mean follow-up of 6 years 2 months.

Use of a collagen matrix for recession coverage in patients who received orthodontic therapy: a case series.

Aim: The aim of the present study was to determine the percentage of recession coverage achieved following surgery with a collagen matrix, and patient-reported outcome measures.

Methods: Five healthy adults who had completed orthodontic therapy with a gingival recession defect were recruited. Gingival recession coverage was performed using a two-layer, xenogeneic collagen matrix (Mucograft).

Effects of enamel matrix derivative and transforming growth factor-β1 on connective tissue growth factor in human periodontal ligament fibroblasts.

Background: Enamel matrix derivative (EMD) is suggested to stimulate transforming growth factor-β (TGF-β) production. Connective tissue growth factor (CTGF) is a downstream mediator of TGF-β. This study explores the effects of EMD and TGF-β1 on CTGF in periodontal ligament (PDL) fibroblasts and their interactions in PDL proliferation and development.

Patient-reported outcome measures after routine periodontal and implant surgical procedures.

Objectives: To compare patient-reported outcome measures (PROMs) after different dental surgical procedures over a 1-week post-surgical period and in relation to duration of the surgery, and periosteal releasing incisions. To evaluate the prevalence of post-surgical complications.

Material & Methods: Four hundred and sixty-eight healthy dental patients requiring surgeries, such as crown lengthening (CL), open flap debridement (OFD) and implant installation (IMP) in the National Dental Centre, Singapore (2009-2011), were consecutively recruited.

Principles and implications of site preservation for alveolar ridge development.

The extraction of a tooth normally results in the loss of ridge height and width. Often, clinicians are faced with the management of edentulous sites that are less than optimal for prosthetic rehabilitation and implant restoration due to considerable alveolar ridge collapse after tooth removal. Site preservation using bone grafts or substitutes with and without a membrane maintain ridge dimensions and contours.

Periodontic and orthodontic treatment in adults.

The purpose of this article is to provide an update of the interrelationship between periodontics and orthodontics in adults. Specific areas reviewed are the reaction of periodontal tissue to orthodontic forces, the influence of tooth movement on the periodontium, the effect of circumferential supracrestal fiberotomy in preventing orthodontic relapse, the effect of orthodontic treatment on the periodontium, microbiology associated with orthodontic bands, and mucogingival and esthetic considerations. In addition, the relationship between orthodontics and implants (eg, using dental implants for orthodontic anchorage) is discussed.