Publications by authors named "Marianne Chanti-Ketterl"
Article Synopsis
- Traumatic brain injuries (TBIs) are linked to a higher risk of dementia, and this study investigates how a lifetime of TBIs impacts cognitive decline in aging individuals, particularly using twin data to control for genetic and environmental factors.
- The research involved male World War II veterans from a twin registry, who reported TBIs and underwent cognitive assessments over 12 years, revealing that TBIs, especially those with loss of consciousness or experienced at older ages, are associated with lower cognitive scores and faster decline.
- Key findings showed that 25% of participants had TBIs, and those with multiple TBIs or TBIs at older ages experienced significant cognitive decline, highlighting the need for targeted cognitive interventions for TBI sufferers.
Cognitive aging is a lifelong process with implications for Alzheimer's disease and dementia. This study aims to fill major gaps in research on the natural history of and social disparities in aging-related cognitive decline over the life span. We conducted integrative data analysis of four large U.
View Article and Find Full Text PDFBackground: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially available computerized cognitive training program targeting improved Useful Field of View Training (UFOVT) performance. The primary goal is to test the effectiveness of UFOVT to reduce incidence of clinically defined mild cognitive impairment (MCI) or dementia with a secondary objective to examine if effects are moderated by plasma β-amyloid level or apolipoprotein E e4 (APOE e4) allele status.
View Article and Find Full Text PDFIntroduction: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia.
Methods: Members of the National Academy of Sciences-National Research Council's Twins Registry of World War II male veterans were assigned a cognitive outcome based on a multi-step assessment protocol. History of TBI was obtained via interviews.
Background: Dysregulation of some metabolic factors increases the risk of dementia. It remains unclear if overall metabolic dysregulation, or only certain components, contribute to cognitive aging and if these associations are sex specific.
Methods: Data from the 2006-2016 waves of the Health and Retirement Study (HRS) was used to analyze 7 103 participants aged 65 and older at baseline (58% women).
Article Synopsis
- This study investigates how body mass index (BMI) changes throughout a person's life and the impact of social factors like race and education on these changes, filling a gap in existing research.
- Researchers combined data from four major longitudinal studies to analyze BMI trends from adolescence to old age, focusing on differences among various birth cohorts.
- The findings reveal that BMI increases more significantly in recent generations, with persistent disparities based on race and education, particularly affecting women more than men.
Introduction: The Alzheimer's Disease Prevention Registry (ADPR) of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center at Duke University has been successful in achieving a racially diverse and "research ready" cohort of cognitively healthy volunteers.
Methods: The ADPR is based on an infrastructure that includes: (1) an administrative leadership team; (2) a coordinating center; (3) an IT management team; (4) a community engagement team; and (5) collaborations with study partners across disciplines.
Results: The ADPR currently has more than 4677 members, 26% of whom are African American.
The National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917-1927 (N = 31.848), both of whom served in the armed forces, chiefly during World War II.
View Article and Find Full Text PDFWe used the Physical Performance Across the LifeSpan Study to investigate the relationships of multiple indicators of socioeconomic status (SES), both in early life and late life, with physical function. We examined associations between multiple early and late life SES indicators with physical function measured by aerobic endurance, gait speed, and lower body strength. Higher participant education and household income were associated with increased physical function.
View Article and Find Full Text PDFObjective: To examine the relationship between total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) with disability and physical performance.
Method: Wave 1 data were from Costa Rican Longevity and Healthy Aging Study ( n = 2,827). Lipoprotein profiles were measured using blood samples.
Objective: This study examined the cross-sectional association between phytoestrogens and speed of processing. We hypothesized that higher levels of phytoestrogens would be related to better cognitive performance among older women.
Methods: Participants were from the National Health and Nutrition Examination Survey and consisted of 200 older women (M = 74.
Background: Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured with six well-established cognitive domains and a composite cognitive score (CCS).
Methods: In this cross-sectional study, biomarkers and neuropsychological assessment were available for 141 adults with MMSE scores ≥ 24 (mean age = 69 years, 47% female, mean education = 14.
Objective: Percutaneous coronary intervention (PCI) is the first line of treatment for ST-elevated myocardial infarction (STEMI). This study evaluates the role of dementia in diagnostic cardiac catheterization (to receive PCI) in STEMI patients ≥65 years old admitted to high annual volume PCI hospitals.
Methods: Participants were registered in Florida's comprehensive inpatient surveillance system for the years 2006-2007 with principal diagnosis of STEMI.