Publications by authors named "Marianna Sartorelli"
Article Synopsis
- * A study compared 46 patients treated with angiotensin II to 53 control patients, finding that it significantly increased mean arterial pressure and improved oxygenation while reducing liver dysfunction odds.
- * The results suggest that angiotensin II may help reduce the need for renal replacement therapy in patients with pre-existing kidney issues, but these findings are preliminary and require further investigation.
Background: COVID-19 is associated with elevated levels of inflammatory cytokines. We present the characteristics and outcomes of patients treated in the Intensive Care Unit (ICU) with immunosuppressive drugs, either tocilizumab or anakinra compared with controls.
Methods: A single-center observational prospective study on ICU invasively ventilated COVID-19 patients.
Background: In the first wave of the novel coronavirus (severe acute respiratory syndrome coronavirus 2) infections, Italy experienced a heavy burden of hospital admissions for acute respiratory distress syndromes associated with the novel coronavirus disease (COVID-19). Early evidence suggested that females are less affected than males.
Objective: This study aimed to assess the gender-related differences in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital, Milan, Italy.
Background: The Lombardy region, in Northern Italy, suffered a major outbreak of Coronavirus disease 2019 (COVID-19) at the end of February 2020. The health system was rapidly overwhelmed by the pandemic. It became evident that patients suffering from time-sensitive medical emergencies like stroke, cerebral hemorrhage, trauma and acute myocardial infarction required timely, effective and safe pathways to be treated.
View Article and Find Full Text PDFObjective: Describe characteristics, daily care and outcomes of patients with coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS).
Design: Case series of 73 patients.
Setting: Large tertiary hospital in Milan.
Article Synopsis
- A study in Milan examined acute kidney injury (AKI) and the use of continuous renal replacement therapy (CRRT) in COVID-19 patients on mechanical ventilation, finding that 75% developed AKI and nearly 18% required CRRT.
- Most AKI cases were mild (stage 1), but there was a significant mortality risk, with 38.9% of the AKI patients and 52.9% of those receiving CRRT dying during their hospital stay.
- The research highlights that older patients and those with pre-existing chronic kidney disease (CKD) were more likely to develop AKI or need CRRT, indicating higher vulnerability in this group.
At the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak spread from China all around the world, causing thousands of deaths. In Italy, the hardest hit region was Lombardy, with the first reported case on 20 February 2020. San Raffaele Scientific Institute — a large tertiary hospital and research centre in Milan, Italy — was immediately involved in the management of the public health emergency.
View Article and Find Full Text PDFObjectives: Epinephrine is frequently used as an inotropic and vasopressor agent in critically ill patients requiring hemodynamic support. Data from observational trials suggested that epinephrine use is associated with a worse outcome as compared with other adrenergic and nonadrenergic vasoactive drugs. We performed a systematic review and meta-analysis of randomized controlled trials to investigate the effect of epinephrine administration on outcome of critically ill patients.
View Article and Find Full Text PDF