Publications by authors named "Marianna Sanna"
Despite growing public awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior is challenging because it appears to be driven by addictive mechanisms. This can have effects on health because sun exposure, although beneficial, when prolonged and repeated shows a causal relationship with skin cancer risk. Using data from 2,500 United Kingdom twins, we observed sun seeking to be significantly heritable (h2 ≥ 58%).
View Article and Find Full Text PDFArticle Synopsis
- - A large meta-analysis involving genome-wide association studies (GWAS) of nearly 37,000 melanoma cases revealed 54 significant genetic locations (loci) linked to the disease, advancing our understanding of its genetic risk factors.
- - The study found that the acral melanoma subtype is not influenced by pigmentation, suggesting distinct genetic mechanisms compared to other melanoma types.
- - By combining findings from various genetic studies, researchers identified a total of 85 loci related to cutaneous melanoma, highlighting factors such as nevus count, pigmentation, and telomere maintenance as important in melanoma development.
Body site-specific genetic effects influence naevus count distribution in women.
Pigment Cell Melanoma Res
March 2020
Body site is highly relevant for melanoma: it affects prognosis and varies according to the patient's sex. The distribution of naevi, a major risk factor for melanoma, at different body sites also varies according to sex in childhood. Using naevus counts at different body sites in 492 unrelated adults from both sexes, we observed that women have an increased number of naevi on the lower limbs compared to men (p = 8.
View Article and Find Full Text PDFThe original version of this Article contained errors in the spelling of the authors Fan Liu and M. Arfan Ikram, which were incorrectly given as Fan Lui and Arfan M. Ikram.
View Article and Find Full Text PDFThe total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs in KITLG and a region of 9q32.
View Article and Find Full Text PDFThe skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci.
View Article and Find Full Text PDFArticle Synopsis
- A genome-wide association meta-analysis of body fat percentage (BF%) was conducted with data from 100,716 individuals to explore the genetic basis of adiposity and its connection to cardiometabolic diseases.
- Twelve genetic loci were identified as significantly associated with BF%, including eight known for overall adiposity and four novel loci.
- Findings indicate that some loci have a stronger effect on BF% compared to BMI, suggesting they are primarily linked to fat, while others influence both fat and lean mass, offering new insights into the relationship between body fat and disease risk.