Publications by authors named "Marianna Moro"
Article Synopsis
- - Tumour angiogenesis is crucial for supplying malignant cells with oxygen and nutrients, facilitating their invasion and spread, often resulting in the formation of disorganized and leaky blood vessels due to cytokine activity.
- - Nicotinamide phosphoribosyltransferase (eNAMPT) is elevated in many cancers, acting not only as a necessary enzyme for energy production but also as a pro-inflammatory cytokine that correlates with cancer aggressiveness and prognosis, especially in breast cancer.
- - In triple-negative breast cancer, eNAMPT promotes angiogenesis and metastasis by attracting NG2 pericytes and activating pro-inflammatory signaling, with potential therapeutic effects demonstrated by neutralizing eNAMPT with an antibody, pointing towards new anti-
Management of anesthesia in children with autism spectrum disorders.
Minerva Anestesiol
September 2024
Pericytes, recognized as mural cells, have long been described as components involved in blood vessel formation, playing a mere supporting role for endothelial cells (ECs). Emerging evidence strongly suggests their multifaceted roles in tissues and organs. Indeed, pericytes exhibit a remarkable ability to anticipate endothelial cell behavior and adapt their functions based on the specific cells they interact with.
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- The study investigates the potential relationship between autism spectrum disorder (ASD) and joint hypermobility (JH) in a cohort of 67 non-syndromic children, aged 2-18 years, with varying levels of cognitive impairment and autism severity.
- Findings reveal that a noteworthy percentage (63% of ages 2-4 and 73% of ages 5+) of ASD patients display significant signs of hypermobility.
- The study concludes that joint hypermobility might be a relevant characteristic in ASD patients, suggesting that it should be evaluated to enhance rehabilitation strategies, though no strong link was found between hypermobility and cognitive or autism severity scores.
Perinatal stroke is related to possible differences in predisposing factors and outcomes between acutely and retrospectively diagnosed cases. In most cases, there are different risk factors and infections that could play an important role. Thus far, different clinical manifestations have been reported in children presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from asymptomatic status to severe disease sustained by an immune-mediated inflammatory response.
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- The study explores the connection between protein synthesis deregulation and ER stress in astrocytes related to Alzheimer's disease, specifically in a model using 3xTg-AD mice.
- It highlights the impairment of protein synthesis in 3Tg-iAstro cells characterized by increased levels of phosphorylated eIF2α and reduced GADD34, while showing that these changes occur independently of typical ER stress markers such as PERK and ATF4.
- Additionally, the research found that astrocytes from 3xTg-AD mice negatively affect the function and structure of nearby neurons and cells, but treatment with a chemical chaperone (4-PBA) improved protein synthesis and cell interactions in culture.
Article Synopsis
- * A β-cyclodextrin modified with dipeptide-like urea arms serves as a promising vehicle for delivering drugs selectively to PSMA-overexpressing prostate cancer cells.
- * The system was tested using fluorescein to confirm targeting abilities, showing that doxorubicin combined with the β-cyclodextrin complex works faster to kill prostate cancer cells than doxorubicin alone.
Unlabelled: This study aims to evaluate the efficacy of the PECARN Rule (PR) in reducing radiological investigations in children with mild traumatic head injury in comparison with current clinical practice. A retrospective study was performed in our hospital between July 2015 and June 2020. Data of all children < 18 years of age admitted to the emergency department (ED), within 24 h after a head trauma with GCS ≥ 14, were analyzed.
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- Tumor cells adapt their metabolism to support uncontrolled growth by requiring sufficient levels of NAD and NADPH.
- *NAD is a key cofactor for important enzymes like PARPs and sirtuins, while NADPH helps regulate cellular redox status.
- *The review discusses strategies for targeting the enzymes that sustain the NAD/NADPH pool in colorectal cancer and how these enzymes interact with NADP(H).