Publications by authors named "Marianna Guardascione"
Article Synopsis
- * The first occurrence of EVB is influenced by the severity of portal hypertension and liver disease, along with the size and appearance of esophageal varices, with HVPG and EGD being key diagnostic methods.
- * Recent studies suggest that computed tomography (CT) could offer a non-invasive alternative for predicting EVB risk, but more evidence is needed to confirm its effectiveness compared to current methods like EGD and HVPG.
Aim: To investigate possible abnormalities of vasoactive compounds, nitrative stress, and antioxidant activity of paraoxonase (PONa) in human hepatopulmonary syndrome (HPS), we determined endothelin-1 (ET), nitric oxide (NOx) metabolites, PONa alongside crude plasma nitrotyrosine (NT) as surrogate marker of nitrative stress.
Material And Methods: Liver cirrhosis (LC) patients with HPS (n = 12) were matched by age, sex, and Child-Pugh score to LC patients without HPS (n = 15) and to healthy controls (CTR) (n = 15); plasma NO2(-) (nitrite) (vascular metabolite), NO3(-) (nitrate) (inflammatory metabolite), and PONa were determined by a colorimetric assay, ET, and NT by immunoassays.
Results: HPS patients showed higher level of ET (p = 0.