Publications by authors named "Marianeve Grieco"
Article Synopsis
- IL-17 is a proinflammatory cytokine that enhances the expression of various cytokines and chemokines by promoting gene transcription and stabilizing mRNAs.
- The study reveals that IL-17 increases the half-life of Zc3h12a mRNA through an interaction between the adaptor protein CIKS and the DEAD box protein DDX3X, requiring the helicase domain of DDX3X.
- Knockdown of DDX3X reduces the stability of Zc3h12a mRNA without impacting other mRNAs, and additional proteins like IKKε and TNFR-associated factors are also necessary for this mRNA stabilization process triggered by IL-17.
