Publications by authors named "Mariane Uehara de Souza"
The embryo mosaicism profile of next-generation sequencing PGT-A in different clinical conditions and their associations.
Hadassa Campos Heiser Natalia Fagundes Cagnin Mariane Uehara de Souza Taccyanna Mikulski Ali Paula Regina Queiroz Estrada Camila Cristina Wuaquim Dantas de Souza
Front Reprod Health
March 2023
Article Synopsis
- Uniform chromosome abnormalities are frequently seen in early pregnancy loss, with mosaic autosomal trisomy present in about 10% of cases, highlighting the need for further understanding of its clinical implications.
- A study analyzed data from a large PGT-A database in Brazil between 2019 and 2022 to evaluate the prevalence of mosaicism in embryos, including factors related to maternal age, embryo development day, and quality.
- Results showed that most mosaic aneuploidies were linked to the last three chromosomes, with various associations found for different clinical conditions, indicating that maternal age and embryo quality significantly affect mosaicism rates.