Publications by authors named "Mariane Pivard"
Staphylococcus aureus gamma-hemolysin CB (HlgCB) is a core-genome-encoded pore-forming toxin that targets the C5a receptor, similar to the phage-encoded Panton-Valentine leucocidin (PVL). Absolute quantification by mass spectrometry of HlgCB in 39 community-acquired pneumonia (CAP) isolates showed considerable variations in the HlgC and HlgB yields between isolates. Moreover, although HlgC and HlgB are encoded on a single operon, their levels were dissociated in 10% of the clinical strains studied.
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- The study investigates how different levels of expression of virulence proteins in a bacterial pathogen relate to the severity of staphylococcal pneumonia in patients, highlighting the challenges of measuring these levels consistently.
- Using a targeted proteomics technique, the researchers analyzed 136 isolates from French patients and identified specific virulence factors that predict severe symptoms like leukopenia and hemoptysis, as well as patient survival.
- Notably, the expression of the Panton-Valentine leucocidin was found to be a significant predictor of mortality, suggesting that targeted proteomics could be valuable for understanding infection dynamics in other bacterial diseases.
is both a commensal and a pathogenic bacterium for humans. Its ability to induce severe infections is based on a wide range of virulence factors. community-acquired pneumonia (SA-CAP) is rare and severe, and the contribution of certain virulence factors in this disease has been recognized over the past 2 decades.
View Article and Find Full Text PDFAgrobacterium fabrum C58 is a plant-associated bacterium that is able to denitrify under anoxic conditions. The cluster of denitrification genes harbored by this strain has been well characterized. It includes nir and nor operons encoding nitrite and nitric oxide reductases, respectively.
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