Publications by authors named "Mariana dos Santos Lunardi"

Article Synopsis
  • The systematic review evaluates the impact of the ketogenic diet (KD) on cognitive function in children and adults with pharmacoresistant epilepsy, which affects both neurological health and quality of life.
  • Out of 24 studies reviewed, 19 reported improvements in cognitive function linked to KD, while a few showed mixed results, indicating the need for standardized methods of assessing cognition.
  • The review concludes that there is insufficient evidence to confirm the KD's benefits on cognitive function, calling for more rigorous research with larger, more consistent participant groups and better study designs.
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Background: Although ketogenic diet therapy (KDT) is a well-established, nonpharmacologic therapeutic option for patients with pharmacoresistant epilepsy, its availability is still not widespread. The COVID-19 pandemic may have further restricted the access of people with pharmacoresistant epilepsy (PWE) to KDT. Thus, we evaluated the experiences of Brazilian PWE and their caregivers during the first year of the pandemic.

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Background: The coronavirus disease 2019 (COVID-19) outbreak impacted the lives of worldwide people with epilepsy (PWE) in various aspects, particularly in those countries most significantly affected by this pandemic, such as Brazil. We aimed to investigate the prevalence of depressive symptoms in PWE and their correlation with epilepsy features and access to treatment.

Methods: PWE were invited to answer a cross-sectional online-based survey to assess and rate depressive symptoms using the NDDI-E during the first year of the COVID-19 pandemic and its relation to multiple lifestyles epilepsy clinical aspects.

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Migraine and epilepsy are both common episodic disorders, typically precipitated or inhibited by some modulatory factors (MFs). To assess the self-perception of MFs in patients with migraine (PWM) compared to patients with epilepsy (PWE) with a standardized protocol in different countries. Transcultural multicenter comparative cross-sectional study.

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Article Synopsis
  • The study aimed to adapt the Global Assessment of Severity of Epilepsy (GASE) and Global Assessment of Disability (GAD) scales into Brazilian Portuguese and compare self-reported scores from patients with those from their physicians.
  • A multicenter study involved 138 patients from five epilepsy centers in Brazil, who completed the GASE and GAD questionnaires along with other validated scales, while 20 attending physicians provided their ratings.
  • The results showed that the GASE and GAD scales were easy for patients to understand, demonstrated a significant correlation between patient self-ratings and physician ratings, and highlighted the impact of epilepsy on patients' lives.
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Hygienic and sanitary measures and social distancing policies implemented during the new coronavirus disease - COVID-19 - pandemic have altered the care and follow-up provided by healthcare professionals for patients with chronic diseases, including patients with epilepsy (PWEs). Telemedicine has become a solution for the healthcare of PWEs in many developed countries. In this short communication, we trace a particular perspective for the application of telemedicine for PWEs undergoing ketogenic diet (KD) treatment, considering the social and economic difficulties faced by healthcare teams in resource-poor countries, such as Brazil.

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A ketogenic diet may be a therapeutic option for approximately one third of patients with epilepsy. These patients continue to have seizures despite suitable pharmacological treatment. Regardless of the diet's therapeutic potential regarding seizure control, adverse events may coexist.

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Epileptic seizures may be triggered by both nonspecific facilitating factors and specific reflex epileptic mechanisms. These consist of sensory or cognitive inputs activating neural networks that, due to some functional instability, may respond with an epileptic discharge. The aim of this study was to determine the prevalence and nature of self-perceived seizure-inducing and -inhibiting factors in patients with mesial temporal lobe epilepsy (MTLE) followed from March 3rd to December 8th, 2009 at the Centro de Epilepsia de Santa Catarina Outpatient Clinic of the Hospital Governador Celso Ramos in Florianópolis, Brazil and their relation to demographics, epilepsy-related variables and anxiety level.

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Epilepsy may restrict the patient's daily life. It causes lower quality of life and increased risk for work-related accidents (WRA). The aim of this study is to analyze the implantation of the Epidemiologic and Technical Security System Nexus (ETSSN) and WRA patterns among patients with epilepsy.

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