Pregnancy has no significant impact on the prognosis of differentiated thyroid cancer.

Objective: To evaluate the impact of pregnancy on differentiated thyroid carcinomas (DTC) behavior.

Methods: Retrospective study of patients diagnosed with DTC before or during pregnancy and treated with standard therapy. In women diagnosed with DTC before pregnancy, we evaluated the occurrence of progression according to categories of response to therapy based on imaging and non-stimulated thyroglobulin (TG) levels.

Prognostic factors in patients with advanced differentiated thyroid cancer treated with multikinase inhibitors - a single Brazilian center experience.

Objective: The aim of this study was to describe the real-world experience multikinase inhibitors (MKI) in the treatment advanced differentiated thyroid carcinoma (DTC) refractory to radioactive iodine (RAIR) therapy.

Methods: We reviewed the records of all patients with MKI-treated DTC from 2010 to 2018. Progression free survival (PFS), response rates (RR) and adverse events (AE) profiles were assessed.

High thyroglobulin and negative whole-body scan: no long-term benefit of empiric radioiodine therapy.

Purpose: Around 10-27% of patients will present elevated thyroglobulin (Tg) levels and negative diagnostic whole-body scan (dxWBS) during differentiated thyroid cancer (DTC) follow-up. Empiric radioactive iodine (RAI) therapy in this context is controversial due to the lack of good quality studies in the context. The main purpose of this study is to compare long-term response to therapy status and overall survival between empiric RAI treated and untreated DTC patients.

Cholestatic syndrome as initial manifestation of pancreatic metastasis of papillary thyroid carcinoma: case report and review.

Most papillary thyroid carcinomas (PTC) harbor excellent prognosis. Although rare, distant metastases normally occur in lungs and/or bones. Here we describe a rare case of pancreatic metastasis presenting with rapid onset cholestatic syndrome.

Indirect and direct costs of treating patients with ankylosing spondylitis in the Brazilian public health system.

Introduction: Patients with ankylosing spondylitis require a team approach from multiple professionals, various treatment modalities for continuous periods of time, and can lead to the loss of labour capacity in a young population. So, it is necessary to measure its socio-economic impact.

Objectives: To describe the use of public resources to treat AS in a tertiary hospital after the use of biological medications was approved for treating spondyloarthritis in the Health Public System, establishing approximate values for the direct and indirect costs of treating this illness in Brazil.

The chinchilla eye: morphologic observations, echobiometric findings and reference values for selected ophthalmic diagnostic tests.

Purpose: To carry out a descriptive investigation into the most relevant morphological features of the chinchilla eye and bony orbit, as well as to perform selected ophthalmic diagnostic tests with the aim of establishing normal anatomic and physiologic references for this species.

Method: A total of 57 healthy, chinchillas were used to test most of the parameters in this investigation. Besides morphologic observations of the globe and adnexa, selected ocular tests and parameters were investigated, including blink frequency, palpebral fissure length (PFL), Schirmer tear test (STT), esthesiometry, intraocular pressure (IOP), central corneal thickness (CCT), B-mode echobiometric measurements of the globe and culture of the normal conjunctival bacterial microbiota.

The capybara eye: clinical tests, anatomic and biometric features.

Purpose: To carry out a descriptive investigation of the capybara (Hydrochaeris hydrochaeris) eye and to perform selected ophthalmic diagnostic tests with the aim of establishing normal physiological reference values for this species.

Method: A total of 22 healthy, capybaras were used to test most of the parameters in this investigation. Ages varied from 2 to 4 years of age.