Publications by authors named "Mariana Tavares Ramos"
Article Synopsis
- Oral transmission is currently the main way Chagas disease spreads in the Brazilian Amazon, with symptoms including swelling and bleeding issues.
- In a study with BALB/c mice, researchers found that oral infection led to higher levels of pro-inflammatory cytokines and caused significant blood abnormalities like leukocytosis and thrombocytopenia.
- The findings highlight how oral Chagas infection disrupts the hemostatic system and underscore the importance of the connection between inflammation and hemostasis in this disease.
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed the importance of parasite contact with oral cavity to induce a highly severe acute disease in mice.
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