Publications by authors named "Mariana Tatsch"
Unlabelled: Neuropsychiatric symptoms and caregiver burden are highly prevalent in older adults with Alzheimer's disease (AD).OBJECTIVE: To evaluate the correlation between neuropsychiatric symptoms and caregiver burden in a community-based sample from São Paulo, Brazil.
Methods: A total of 1,563 randomly-selected subjects were assessed by the Mini-Mental State Examination, Fuld Object Memory Evaluation, Informant Questionnaire on Cognitive Decline in the Elderly and Bayer - Activities of Daily Living Scale.
Estimate of dementia prevalence in a community sample from São Paulo, Brazil.
Dement Geriatr Cogn Disord
February 2009
Article Synopsis
- The study aimed to estimate the prevalence of dementia and understand its causes in a community sample from São Paulo, Brazil.
- Involving subjects over 60, the research diagnosed dementia in 6.8% of participants, with Alzheimer's disease being the most common cause, followed by vascular dementia.
- The findings suggest a higher prevalence of dementia in Brazil than previously thought, highlighting the need for further studies to assess the impact on health services in the region.
Article Synopsis
- The study investigated the use of proton magnetic resonance spectroscopy ((1)H-MRS) to identify metabolic changes in elderly individuals with Alzheimer's disease (AD) and those with cognitive impairment, no dementia (CIND).
- The sample included 13 AD patients, 12 CIND patients, and 15 normal individuals, with metabolic metabolites measured in specific brain regions.
- Findings indicated that parietal choline levels were higher in healthy controls and lower in CIND patients, while a combination of metabolites from different brain regions could assist in diagnosing and monitoring cognitive issues in the elderly.
Aims: To present the prevalence of cognitive and functional impairment (CFI) in community-dwelling elderly subjects from the city of São Paulo.
Methods: The population was aged 60 years and older (n = 1,563; 68.7% women and 31.
Objective: This study aimed at estimating the prevalence of cognitive and functional impairment (CFI) in a community sample in Ribeirão Preto, Brazil, evaluating its distribution in relation to various socio-demographic and clinical factors.
Methods: The population was a representative sample aged 60 and older, from three different socio-economic classes. Cluster sampling was applied.
Neuropsychiatric symptoms in Alzheimer disease and cognitively impaired, nondemented elderly from a community-based sample in Brazil: prevalence and relationship with dementia severity.
Am J Geriatr Psychiatry
May 2006
Objectives: The objectives of this study were to describe the prevalence of neuropsychiatric symptoms of dementia in Alzheimer disease (AD) and cognitively impaired nondemented (CIND) subjects from a community-based Brazilian sample and to correlate these symptoms with severity of cognitive deficits.
Method: A total of 1,563 randomly selected subjects were evaluated with the following screening tests: Mini-Mental Status Examination, Fuld Object Memory Evaluation, Informant Questionnaire on Cognitive Decline in the Elderly, and Activities of Daily Living-International Scale. Screen positives were submitted to a workup for dementia, physical and neurologic examination, cranial computed tomography or cerebral magnetic resonance imaging, the Cambridge Examination for Mental Disorders, Clinical Dementia Rating Scale (CDR), and the Neuropsychiatric Inventory (NPI).
Article Synopsis
- The study aimed to analyze proton magnetic resonance spectroscopy (1H-ERM) data in Alzheimer's disease (AD) and Cognitive Impairment Not Dementia (CIND) in a community sample.
- Investigated subjects included 6 with AD, 7 with CIND, and 7 normal controls, focusing on brain metabolites like N-acetylaspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI) across different brain regions.
- The results showed that NAA levels were highest in controls, and specific metabolite patterns could correctly classify most subjects with AD versus controls and CIND versus controls, indicating the potential of spectroscopy for diagnosing cognitive impairment.