Electrospun Coaxial Polycaprolactone/Polyvinylpyrrolidone Fibers Containing Cisplatin: A Potential Local Chemotherapy Delivery System for Cervical Cancer Treatment.

Cisplatin, a frequently used chemotherapeutic for the treatment of cervical cancer, causes adverse effects that limit its use. Treatment with local therapy that limits toxicity remains a challenge. The aim of this study was to develop a local intravaginal cisplatin delivery system of polycaprolactone/polyvinylpyrrolidone sheath/core fibers by coaxial electrospinning.

The Era of Biomaterials: Smart Implants?

Conditions, accidents, and aging processes have brought with them the need to develop implants with higher technology that allow not only the replacement of missing tissue but also the formation of tissue and the recovery of its function. The development of implants is due to advances in different areas such as molecular-biochemistry (which allows the understanding of the molecular/cellular processes during tissue repair), materials engineering, tissue regeneration (which has contributed advances in the knowledge of the properties of the materials used for their manufacture), and the so-called intelligent biomaterials (which promote tissue regeneration through inductive effects of cell signaling in response to stimuli from the microenvironment to generate adhesion, migration, and cell differentiation processes). The implants currently used are combinations of biopolymers with properties that allow the formation of scaffolds with the capacity to mimic the characteristics of the tissue to be repaired.