Synthesis and biological evaluation of 12 novel (-)-camphene-based 1,3,4-thiadiazoles against .

To evaluate the activity, cytotoxicity and efflux pumps inhibition of a series of 12 novels (-)-camphene-based 1,3,4-thiadiazoles (TDZs) against (). The minimum inhibitory concentration (MIC), cytotoxicity for three cell lines, ethidium bromide accumulation and checkerboard methods were carried out. Compounds (, , , , and ) showed significant anti- activity (MIC 3.