Publications by authors named "Mariana Renee Miranda"
X-ray diffraction and in vivo studies reveal the quinary structure of Trypanosoma cruzi nucleoside diphosphate kinase 1: a novel helical oligomer structure.
Juan Arturo Gomez Barroso Mariana Reneé Miranda Claudio Alejandro Pereira Richard Charles Garratt Carlos Fernando Aguilar
Acta Crystallogr D Struct Biol
January 2022
Trypanosoma cruzi is a flagellated protozoan parasite that causes Chagas disease, which represents a serious health problem in the Americas. Nucleoside diphosphate kinases (NDPKs) are key enzymes that are implicated in cellular energy management. TcNDPK1 is the canonical isoform in the T.
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- Arginine kinase (AK) is an enzyme linked to allergic reactions in invertebrates and is also present in the parasite T. cruzi, which causes Chagas disease.
- The study investigated the presence of specific antibodies against T. cruzi AK (TcAK) in patients with chronic Chagas disease (CCD) and found differing levels of IgG and IgE antibodies between infected and non-infected individuals.
- Results suggest that TcAK might play a role in influencing B cell responses and could contribute to allergic reactions during T. cruzi infection, revealing a potential new target for understanding immune responses in affected patients.