Long- and short-term diabetes mellitus type 1 modify young and elder rat salivary glands morphology.

Objective: In this study we performed a temporal analysis of the effects of Diabetes Mellitus on morphology and laminin deposition in salivary glands of young (2 months-old) and aging (12 months-old) male Wistar rats, using immunohistochemistry.

Materials And Methods: The animals were divided in control and diabetic (Streptozotocin induced) groups and euthanized after short and long-term diabetes induction.

Results: Short-term induction led to vacuolization of parotid acinar cells and increased laminin deposition in both animal ages.