Screening of mutations in the additional sex combs like 1, transcriptional regulator, tumor protein p53, and proto-oncogene, proto-oncogene, genes of patients with myelodysplastic syndrome.

Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal bone marrow disorders characterized by ineffective hematopoiesis, different degrees of cellular dysplasia, and increased risk of progression to acute myeloid leukemia. International Prognostic Scoring System is the gold standard for MDS classification; however, patients exhibiting different clinical behaviors often coexist in the same group, indicating that the currently available scoring systems are insufficient. The genes that have recently been identified as mutated in MDS, including additional sex combs like 1, transcriptional regulator (), tumor protein p53 (), and proto-oncogene and ()/ proto-oncogene, (), may contribute to a more comprehensive classification, as well as to the prognosis and progression of the disease.

Cytogenetic analysis of experimental hybrids in species of Triatominae (Hemiptera-Reduviidae).

A cytogenetic analysis was performed in experimental hybrids between species of Chagas disease transmitting bugs with remarkable differences in the amount and distribution of heterochromatin. Using C-banding technique, we identified the parental species chromosomes and analysed the meiotic behaviour in the male hybrids between Triatoma platensis and T. infestans, T.