Publications by authors named "Mariana Marcin Sierra"
Article Synopsis
- Creutzfeldt-Jakob disease (CJD) is a deadly neurological disorder caused by prions, and this study focuses on identifying its clinical characteristics among patients in a Latin American referral center.
- Between 2014 and 2019, researchers reviewed the cases of 24 patients diagnosed with CJD, noting that most were women with an average age of around 59 years and a symptom duration of about 7.5 months before hospitalization.
- Common symptoms included behavioral changes, and diagnostic tests like EEG and MRI revealed significant abnormalities, while cerebrospinal fluid analysis showed positive markers linked to CJD in several cases.
Background: Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). B cells have an essential role in the disease pathogenesis and therefore selective B-cell depletion are commonly used to treat the disease. Rituximab (RTX), a chimeric anti-CD20 monoclonal antibody had demonstrated reduced inflammatory activity and radiological activity in MS patients.
View Article and Find Full Text PDFIntroduction: Multiple sclerosis (MS) is a chronic neurological autoimmune condition and the leading non-traumatic cause of neurological disability worldwide. Disease-modifying therapies (DMT) directly impact on the long-term prognosis of patients with MS preventing relapses and the associated disability progression. Here, we analyzed the impact of socioeconomic status (SES) on DMT access in Mexican patients.
View Article and Find Full Text PDFWe present the case of a 68-year-old woman who developed progressive visuospatial deficits in a period of 18 months, leading to the loss of her independence for activities of daily living. After examination, she showed signs of Balint syndrome with optic ataxia, oculomotor apraxia, and simultanagnosia without visual acuity impairment. After brain imaging showing severe bilateral parieto-occipital association cortex atrophy, a diagnosis of posterior cortical atrophy was made according to the 2017 International Consortium's criteria.
View Article and Find Full Text PDFBackground: Extraparenchymal neurocysticercosis (ExPNCC), an infection caused by Taenia solium cysticerci that mainly occurs in the ventricular compartment (Ve) or the basal subarachnoid space (SAb), is more severe but less frequent and much less studied than parenchymal neurocysticercosis (ParNCC). Demographic, clinical, radiological, and lumbar cerebrospinal fluid features of patients affected by ExPNCC are herein described and compared with those of ParNCC patients.
Methodology And Principal Findings: 429 patients with a confirmed diagnosis of neurocysticercosis, attending the Instituto Nacional de Neurología y Neurocirugía, a tertiary reference center in Mexico City, from 2000 through 2014, were included.