Construction of vicinal 4°/3°-carbons reductive Cope rearrangement.

Herein reported is a strategy for constructing vicinal 4°/3° carbons reductive Cope rearrangement. Substrates have been designed which exhibit Cope rearrangement kinetic barriers of ∼23 kcal mol with isoenergetic favorability (Δ ∼ 0). These fluxional/shape-shifting molecules can be driven forward by chemoselective reduction to useful polyfunctionalized building blocks.

An integrated study of the plankton community after four years of Fundão dam disaster.

Mining activities can affect the environment either by the tailings releasing or dams failures. The impact of the tailings can last decades and cause chronic effects due to their toxicity. The Fundão dam collapse, a relevant environmental disaster, occurred in November 2015 in Southeastern Brazil.