3D-Printed Polycaprolactone Mechanical Characterization and Suitability Assessment for Producing Wrist-Hand Orthoses.

In this research, the mechanical properties of 3D-printed polycaprolactone (PCL), a biocompatible and biodegradable semi-crystalline polyester, available as feedstock for additive manufacturing technology based on the material extrusion process, were determined. The influence of the infill pattern (zig-zag vs. gyroid) and ultraviolet (UV-B) exposure over the specimens' mechanical performances were also investigated to gather relevant data on the process parameter settings for different applications.

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors.

High incidence of cetuximab-related infusion reactions in head and neck patients.

Background: Cetuximab is crucial in the management of squamous cell carcinoma of the head and neck of patients. Grade 3-4 cetuximab-induced infusion reactions (CI-IRs) occur in 2% of patients with colorectal cancer. Despite the 2.

[Therapeutic aspects of acute renal failure in children].

This article presents the results of a study on 20 children diagnosed with acute renal failure and treated with renal substitution methods at the Iasi IVth Clinic of Pediatric Nephrology in the interval 2003-2008. Treatment by intermittent hemodialysis IHD), peritoneal dialysis (DP), and continuous replacement--hemofiltering (HF) depends on the patient's features and unit resources. The advantages and limitations of every method of treatment are discussed.

[Considerations based on the etiology of acute renal failure in children (study on 110 cases)].

The Article highlights the fact that without a homogeneous definition of acute renal injuries of adults and infants, for the last 5 years a new classification system has appeared. The RIFLE pediatric criteria are looked over, validated in 2007 which allow a better IRA classification at infants and allow comparisons between the intensive care units and also allow assumptions on the predictions of the disease. The list of certain causes of IRA at infants is rendered, the genetic background of children with IRA risk is highlighted, the necessity of reevaluating and criteria of evaluating renal functions is underlined.