Publications by authors named "Mariana I Costa"
Metal nanoparticles Biosynthesis Using the Halophilic Archaeon Haloferax volcanii.
Methods Mol Biol
September 2022
Nanoparticle (NP) synthesis using biological resources as reducing agents is an eco-friendly and simple strategy compared to the traditional physical/chemical methods. The ability of microorganisms of the Archaea domain to synthesize metal NPs has been explored to a limited extent. Metal NPs have been applied in several fields including catalysis, agriculture, biomedicine, electronics, and optics.
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- Proteolysis is crucial for various cellular processes like protein quality control, signaling, and cell envelope formation.
- Archaea, a diverse group of prokaryotes, thrive in extreme environments, offering insights into proteases' roles in cell physiology and adaptation.
- This review highlights recent progress on archaeal membrane proteases, particularly their biological functions and potential targets, focusing on a specific model organism known as haloarchaeon.
Article Synopsis
- - Rhomboids are intramembrane serine proteases crucial for cell signaling, but their role in prokaryotes, especially Archaea, is not well understood.
- - A study on a rhomboid homologue deletion mutant (ΔrhoII) in Haloferax volcanii revealed issues like reduced motility and N-glycosylation defects, prompting an analysis of protein changes in the mutant compared to the wild-type strain.
- - Out of 1847 proteins identified, 103 showed differences in quantity and 99 had altered processing, highlighting key proteins linked to motility and glycosylation issues in the mutant, and marking the first investigation of a rhomboid protease's impact