Publications by authors named "Mariana Hollanda Martins da Rocha"
A multicentric observational retrospective study on patients with short bowel syndrome and chronic intestinal failure who underwent intestinal transplantation in Brazil.
Clinics (Sao Paulo)
October 2024
Article Synopsis
- Short Bowel Syndrome (SBS) is a rare gastrointestinal disorder leading to intestinal failure (SBS-IF), and intestine transplantation (IT) is a potential treatment that can help patients return to normal activities.
- This study analyzed the clinical characteristics and outcomes of SBS-IF patients who underwent IT in Brazil from 2011 to 2021, focusing on a small group of young males.
- Key findings reveal that the main reasons for IT included surgical complications and liver disease related to total parenteral nutrition, highlighting the need for insights that could guide health policy and improve patient care.
Article Synopsis
- The study aimed to assess the incidence and severity of COVID-19 among patients receiving home parenteral nutrition (HPN) for chronic intestinal failure over a year-long observation period from March 2020 to March 2021.
- Out of 4680 patients from 68 centers across 23 countries, the cumulative incidence of COVID-19 infection was 9.6%, with 55.1% of patients providing COVID-related data, revealing varying rates of infection severity.
- Results indicated a higher incidence and severity of infection among deceased patients, and significant proportions of the cohort were unvaccinated or had unknown vaccination statuses; 42.8% of deaths in infected individuals were attributed to COVID-19.
Treating short bowel syndrome with pharmacotherapy.
Expert Opin Pharmacother
April 2020
Introduction: Short bowel syndrome (SBS) has traditionally been regarded as a rapidly fatal medical catastrophe. The advent of pharmacological options directly targeting disease pathophysiology justified this review.
Areas Covered: Since the 1970s, home parenteral nutrition has reduced mortality, converting SBS into a chronic and disabling compensated and occasionally curable illness.
The nutritional status of patients submitted to hematopoietic stem cell transplant is considered an independent risk factor, which may influence on quality of life and tolerance to the proposed treatment. The impairment of nutritional status during hematopoietic stem cell transplant occurs mainly due to the adverse effects resulting from conditioning to which the patient is subjected. Therefore, adequate nutritional evaluation and follow-up during hematopoietic stem cell transplant are essential.
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