Patlak plot based on the first 30 minutes post-injection dynamic F-florbetaben positron emission tomography scan separates amyloid-β positive from negative studies.

Objective: This work aims to search for the shortest duration of an early F-florbetaben positron emission tomography (PET) dynamic acquisition to obtain reliable information on the brain amyloid-β (Aβ) deposition and perfusion.

Methods: 25 patients that underwent an early F-florbetaben PET dynamic acquisition starting immediately post-injection (maximum of 60 min duration) were retrospectively included. Reference region-based Patlak plot [Formula: see text] (transference rate to the irreversible compartment) and [Formula: see text] (distribution volume) were computed.

A novel eudesmol derivative from the leaf essential oil of (Annonaceae) and evaluation of the antinociceptive activity.

In the present study, it was evaluated the chemical composition and the antinociceptive activity of the essential oil obtained from the leaves of . Seven compounds corresponding to 96.2% of the crude essential oil were identified.

Cannabis roots: Pharmacological and toxicological studies in mice.

Ethnopharmacological Relevance: There are many studies and therapeutic properties attributed to the flowers and leaves of the Cannabis species, but even with few pharmacological studies, Cannabis sativa L. (Cannabaceae) roots presents several therapeutic indications in folk medicine.

Aim Of The Study: This study aimed to evaluate the anti-inflammatory and spasmolytic effects as well as the toxicological profile of the aqueous extract of Cannabis sativa roots (CsAqEx) in mice.

β-Cyclodextrin complex improves the bioavailability and antitumor potential of cirsiliol, a flavone isolated from (Lamiaceae).

Cirsiliol is a flavone found in many Lamiaceae species with high cytotoxic activity against tumor cell lines. Although cirsiliol is being used in cancer therapy, its pharmacological potential is limited by its low solubility and bioavailability. In this paper, a cirsiliol-β-cyclodextrin inclusion complex was developed in order to increase its solubility and bioavailability.

Effects of a hypoenergetic diet associated with açaí (Euterpe oleracea Mart.) pulp consumption on antioxidant status, oxidative stress and inflammatory biomarkers in overweight, dyslipidemic individuals.

Objective: To evaluate the effects of a hypoenergetic diet (HD)associated with açaí pulp consumption on oxidative stress, antioxidant status and inflammatory biomarkers in overweight, dyslipidemic individuals.

Research Methods & Procedures: A randomized, double-blind, placebo-controlled clinical trial was conducted for 90 days. The study began with a 30-day run-in period, during which the intervention was exclusively a HD.

Neuropharmacological effects of essential oil from the leaves of Croton conduplicatus Kunth and possible mechanisms of action involved.

Ethnopharmacological Relevance: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as "quebra-faca". In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches.

Aim Of The Study: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia.

Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae).

Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as "araticum" and "pinha da Caatinga". We have evaluated the antinociceptive effects of A.

Anti-phytopathogen potential of endophytic actinobacteria isolated from tomato plants (Lycopersicon esculentum) in southern Brazil, and characterization of Streptomyces sp. R18(6), a potential biocontrol agent.

Tomato plants (Lycopersicon esculentum) are highly susceptible to phytopathogen attack. The resulting intensive application of pesticides on tomato crops can affect the environment and health of humans and animals. The objective of this study was to select potential biocontrol agents among actinobacteria from tomato plants, in a search for alternative phytopathogen control.