Publications by authors named "Mariana Farage"
ACTH-dependent Cushing syndrome (CS) due to ectopic ACTH production is most times difficult to manage. The identification of the source of ACTH may take many years. Surgery or chemotherapy for the primary tumor is not always possible.
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- Previous studies indicated allelic loss in the 13q14 chromosomal region related to pituitary tumors, but the role of the RB1 gene was unclear.
- A tumor deletion map was created using samples from 43 acromegaly patients, revealing that 12% of somatotropinomas showed loss of heterozygosity in the region.
- The findings suggest that another tumor suppressor gene, not RB1, might be involved in the development of these tumors, as RB1's role was ruled out and loss of alleles occurred at similar rates in both invasive and non-invasive adenomas.
This report measured the amount of heat released during Ca(2+) transport and ATP hydrolysis by vesicles derived from the sarcoplasmic reticulum of rabbit slow (SM) and fast (FM) muscle. During ATP hydrolysis, part of the chemical energy released is used to translocate Ca(2+) through the membrane (work) and part is dissipated as heat. The amount of heat produced during catalysis increases after formation of the Ca(2+) gradient across the vesicle membrane.
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