Acute cavernous sinus syndrome from metastasis of lung cancer to sphenoid bone.

Cavernous sinus syndrome is a rare entity in oncology reported only in occasional case reports. Optimal therapy is thus poorly defined with rapidly progressive disease dominating the picture. Management includes prompt diagnosis, attempts at stabilization of cranial nerve function, and aggressive control of central pain syndrome.

Signet ring cell perianal paget disease: loss of MUC2 expression and loss of signet ring cell morphology associated with invasive disease.

Perianal Paget disease (PPD) is a rare and heterogeneous neoplasm in which underlying associated adenocarcinoma is a frequent comorbidity. Previous attempts have been made to define the cells of origin of this neoplasm and delineate the discriminating immunohistochemical (IHC) signature of primary versus secondary disease. We report a case of PPD in a 32-year-old male, that displays an unusual multiclonal immunostaining pattern with focal loss of MUC2 expression and simultaneous phenotypic loss of signet ring cell morphology associated with invasive disease.

Cutaneous squamous cell carcinoma of the external auditory canal.

Cutaneous squamous cell carcinoma (SCC) along with basal cell carcinoma (BCC), collectively known as Nonmelanoma skin cancer (NMSC), are the most common cancers in the United States. Squamous cell carcinoma of the skin is less common than BCC, but is known to be more aggressive with a higher mortality rate. Squamous cell carcinoma of the external auditory canal (EAC) is rare when compared to SCC on other cutaneous sites.

Focused microwave phased array thermotherapy for primary breast cancer.

Background: A pilot safety study of focused microwave phased array thermotherapy in the treatment of primary breast carcinomas was conducted.

Methods: Ten patients with breast carcinomas beneath the skin surface that ranged in maximal clinical size from 1 to 8 cm (mean, 4.3 cm) were treated with the breast compressed in the prone position.