Publications by authors named "Mariana Cruz-Almeida"

Article Synopsis
  • This study focuses on cell wall nanoparticles (CWNPs) derived from fungal hyphal cell walls to explore how they affect macrophage immune responses.
  • CWNPs were produced using various inhibitors, leading to distinct types that showed different impacts on macrophage activation and viability.
  • The findings suggest that modifying fungal cell walls results in nanoparticles with unique properties, which may influence immune reactions and therapeutic strategies during antifungal treatments.
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Vanadium is a transition metal that has been added recently to the EU list of Raw Critical Metals. The growing needs of vanadium primarily in the steel industry justify its increasing economic value. However, because mining of vanadium sources (i.

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F901318 (olorofim) is a novel antifungal drug that is highly active against species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the pyrimidine biosynthesis pathway. In this study, the antifungal effects of F901318 against were investigated.

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The growth and development of most fungi take place on a two-dimensional surface or within a three-dimensional matrix. The fungal sense of touch is therefore critical for fungi in the interpretation of their environment and often signals the switch to a new developmental state. Contact sensing, or thigmo-based responses, include thigmo differentiation, such as the induction of invasion structures by plant pathogens in response to topography; thigmonasty, where contact with a motile prey rapidly triggers its capture; and thigmotropism, where the direction of hyphal growth is guided by physical features in the environment.

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