Publications by authors named "Mariana Chantre Justino"
Purpose: Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV)-related disease affecting the upper airway and saliva could be an important non-invasive sampling source for viral screening and clinical monitoring. We investigated whether HPV DNA could be detected in saliva (cellular pellets and supernatant) from RRP patients and influence on clinical manifestation of the disease.
Materials And Methods: In this pilot study, saliva samples from 14 RRP patients were obtained in preoperative condition (n = 7) and in disease-free interval (DFI; n = 7).
Head and neck squamous cell carcinomas (HNSCCs) represent the most common epithelial tumors that arise from mucosa of the oral cavity, pharynx, and larynx. The development of HNSCCs is usually associated with tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. Most HNSCCs are diagnosed in advanced states, leading to a worse clinical outcome.
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- Research on 40 RRP patients found Epstein-Barr virus (EBV) in 11 cases, but no strong connection between EBV infection and RRP severity was established.
- The study highlighted that having RRP since childhood was significantly associated with increased disease severity, suggesting a lack of direct impact from EBV but a link between early diagnosis and worse outcomes.
Article Synopsis
- * A study analyzed 27 papillomatous lesions from RRP patients, finding specific somatic mutations in tumor suppressor genes (TP53 and CDKN2A) in some patients, though no significant link was established between these mutations and the severity of the disease.
- * Methylation analysis showed high rates of promoter methylation in the p14, TP53, and p16 genes across nearly all cases, indicating that HPV may play a role in altering DNA methylation
Neoplasms induced by human papillomavirus (HPV) infection are generally associated to high-risk HPV types. Recurrent respiratory papillomatosis (RRP) is a rare and chronic HPV-related disease characterized by papillomatous lesions in the respiratory tract, usually affecting larynx. RRP rarely comprises malignant transformation since the low-risk HPV-6 and/or HPV-11 are the most commonly found in the disease.
View Article and Find Full Text PDFBackground And Objective: Gas station attendants are occupationally exposed to benzene, toluene, ethylbenzene and xylene (BTEX) compounds and thus more susceptible to the biological effects of this mixture present in gasoline, especially due to the carcinogenicity of benzene. Furthermore, the harmful effects of BTEX exposure may be potentiated by genetic and epigenetic inactivation of critical genes. The objective was to evaluate such gene-BTEX interactions accessing the promoter methylation status of p14ARF, p16INK4A and GSTP1 in peripheral blood leukocyte samples.
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- * Out of 41 patients, juvenile onset RRP was more common (61%) than adult onset RRP (39%), with HPV-6 and HPV-11 being the most detected types among them.
- * The findings suggest a strong link between HPV types 6 and 11 and RRP, highlighting the importance of HPV vaccination as a preventive measure against the disease.
Molecular evidence indicates that alterations in genes involved in the maintenance of genome stability may be related to susceptibility to bladder carcinoma. Our goal was to evaluate the prognostic role of base excision repair (BER) genes in a cohort of patients diagnosed with primary urothelial carcinoma of the bladder (UCB). The levels of all APE1, XRCC1 and POLB transcripts were detected by quantitative real-time PCR (qPCR) technique in tumor samples from 52 patients undergoing transurethral resection (TUR) for primary UCB at the Department of Urology, Brazilian National Cancer Institute, Rio de Janeiro.
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