Publications by authors named "Mariana Brasil de Andrade Figueira"
Microb Pathog
October 2021
Article Synopsis
- Host genetics play a crucial role in determining an individual's resistance or susceptibility to active pulmonary tuberculosis (TB).
- A specific genetic variant, rs10818488 in the TRAF1/C5 gene, is linked to a higher risk of developing TB, with a significant association found in multibacillary cases leading to increased bacterial load in the lungs.
- The study indicates that a "loss-of-function" variant in TRAF1/C5 may lower the production of TNF-α, thereby increasing susceptibility to TB and affecting the clinical severity of the disease.
Article Synopsis
- * The study investigated single-nucleotide variants (SNVs) in specific inflammasome genes in patients with pulmonary TB (PTB), extrapulmonary TB (EPTB), and healthy controls to understand their role in immune responses.
- * Results showed that SNV rs1103577 may offer protection against PTB, while rs1692816 reduces the risk for EPTB, highlighting the need for further investigation into their impact on immune responses, especially concerning IL
